GABAA receptors are differentially sensitive to zinc: dependence on subunit composition

T. G. Smart; S. J. Moss; X. Xie; R. L. Huganir

doi:10.1111/j.1476-5381.1991.tb12337.x

GABA_A receptors are differentially sensitive to zinc: dependence on subunit composition

T. G. Smart, S. J. Moss, X. Xie, R. L. Huganir

School of Medicine

Research output: Contribution to journal › Article › peer-review

202 Scopus citations

Abstract

GABA_A receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABA_A receptors were differentially sensitive to inhibition by zinc; receptors which lacked the γ subunit were inhibited by zinc. Embryonic neurones also exhibited zinc‐sensitive GABA responses, in contrast to adult neurones. This developmentally‐sensitive aspect of GABA_A receptor pharmacology may be partly dependent on expression of the γ subunit. 1991 British Pharmacological Society

Original language	English (US)
Pages (from-to)	1837-1839
Number of pages	3
Journal	British Journal of Pharmacology
Volume	103
Issue number	4
DOIs	https://doi.org/10.1111/j.1476-5381.1991.tb12337.x
State	Published - Aug 1991

Keywords

GABA receptor
GABA receptor subunits
benzodiazepines
cloned GABA receptors
hippocampus
patch clamp
sympathetic ganglia
zinc

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1111/j.1476-5381.1991.tb12337.x

Cite this

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abstract = "GABAA receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABAA receptors were differentially sensitive to inhibition by zinc; receptors which lacked the γ subunit were inhibited by zinc. Embryonic neurones also exhibited zinc‐sensitive GABA responses, in contrast to adult neurones. This developmentally‐sensitive aspect of GABAA receptor pharmacology may be partly dependent on expression of the γ subunit. 1991 British Pharmacological Society",

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KW - patch clamp

KW - sympathetic ganglia

KW - zinc

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