GABAA receptors are differentially sensitive to zinc: dependence on subunit composition

T. G. Smart, S. J. Moss, X. Xie, R. L. Huganir

Research output: Contribution to journalArticlepeer-review

Abstract

GABAA receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABAA receptors were differentially sensitive to inhibition by zinc; receptors which lacked the γ subunit were inhibited by zinc. Embryonic neurones also exhibited zinc‐sensitive GABA responses, in contrast to adult neurones. This developmentally‐sensitive aspect of GABAA receptor pharmacology may be partly dependent on expression of the γ subunit. 1991 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)1837-1839
Number of pages3
JournalBritish Journal of Pharmacology
Volume103
Issue number4
DOIs
StatePublished - Aug 1991

Keywords

  • GABA receptor
  • GABA receptor subunits
  • benzodiazepines
  • cloned GABA receptors
  • hippocampus
  • patch clamp
  • sympathetic ganglia
  • zinc

ASJC Scopus subject areas

  • Pharmacology

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