Gabapentin and pregabalin for the treatment of chronic pruritus

Kazuki M. Matsuda, Divya Sharma, Ariel R. Schonfeld, Shawn G. Kwatra

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for relieving chronic pruritus is explored. The findings from original sources published to date to evaluate the use of gabapentin and pregabalin as antipruritic agents are explored. They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative therapies.

Original languageEnglish (US)
Pages (from-to)619-625.e6
JournalJournal of the American Academy of Dermatology
Volume75
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • gabapentin
  • itch
  • neurogenic itch
  • neuropathic itch
  • pregabalin
  • pruritus
  • uremic pruritus

ASJC Scopus subject areas

  • Dermatology

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