GABAergic neurons in the primate basal forebrain magnocellular complex

Lary C. Walker, Donald L. Price, W. Scott Young

Research output: Contribution to journalArticle

Abstract

Hybridization histochemistry was used to detect messenger ribonucleic acid (mRNA) coding for glutamic acid decarboxylase, the synthesizing enzyme for γ-aminobutyric acid (GABA), in neurons of the nucleus basalis of Meynert and nucleus of the diagonal band of Broca of one rhesus monkey and 4 baboons. GABAergic neurons were distributed among the unlabeled large, hyperchromic Nissl-stained neurons characteristic of this basal forebrain magnocellular complex, although they were infrequent within the dense islands of large cells. Most GABAergic cells were small to medium in size, but some were large and hyperchromic. These findings demonstrate a heterogeneous population of presumably inhibitory neurons in the basal forebrain magnocellular complex of primates.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalBrain Research
Volume499
Issue number1
DOIs
StatePublished - Oct 9 1989

Fingerprint

GABAergic Neurons
Primates
Diagonal Band of Broca
Basal Nucleus of Meynert
Aminobutyrates
Neurons
Septal Nuclei
Glutamate Decarboxylase
Papio
Macaca mulatta
RNA
Enzymes
Population
Basal Forebrain

Keywords

  • Acetylcholine
  • In situ hybridization
  • Nucleus basalis of Meynert
  • Nucleus of the diagonal band of Broca

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

GABAergic neurons in the primate basal forebrain magnocellular complex. / Walker, Lary C.; Price, Donald L.; Scott Young, W.

In: Brain Research, Vol. 499, No. 1, 09.10.1989, p. 188-192.

Research output: Contribution to journalArticle

Walker, Lary C. ; Price, Donald L. ; Scott Young, W. / GABAergic neurons in the primate basal forebrain magnocellular complex. In: Brain Research. 1989 ; Vol. 499, No. 1. pp. 188-192.
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