GABAergic dysfunction in pediatric neuro-developmental disorders

Research output: Contribution to journalArticle

Abstract

The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.

Original languageEnglish (US)
Article number269
JournalFrontiers in Cellular Neuroscience
Volume7
Issue numberDEC
DOIs
StatePublished - Dec 19 2013

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Neuronal Plasticity
gamma-Aminobutyric Acid
Nervous System
Pediatrics

Keywords

  • Circuits
  • Critical period
  • Disease
  • PV interneurons
  • Synaptic plasticity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

GABAergic dysfunction in pediatric neuro-developmental disorders. / Smith-Hicks, Constance L.

In: Frontiers in Cellular Neuroscience, Vol. 7, No. DEC, 269, 19.12.2013.

Research output: Contribution to journalArticle

Smith-Hicks, Constance L. / GABAergic dysfunction in pediatric neuro-developmental disorders.

In: Frontiers in Cellular Neuroscience, Vol. 7, No. DEC, 269, 19.12.2013.

Research output: Contribution to journalArticle

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