GABA sets the tempo for activity-dependent adult neurogenesis

Shaoyu Ge, Dennis A. Pradhan, Guo li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

GABA, a major inhibitory neurotransmitter in the adult brain, activates synaptic and extrasynaptic GABAA receptors, causing hyperpolarization of mature neurons. As in the embryonic nervous system, GABA depolarizes neural progenitors and immature neurons in the adult brain. Several recent studies have suggested that GABA has crucial roles in regulating different steps of adult neurogenesis, including proliferation of neural progenitors, migration and differentiation of neuroblasts, and synaptic integration of newborn neurons. Here, we review recent findings on how GABA regulates adult neurogenesis in the subventricular zone of the lateral ventricles and in the dentate gyrus of the hippocampus. We also discuss an emerging view that GABA serves as a key mediator of neuronal activity in setting the tempo of adult neurogenesis.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalTrends in Neurosciences
Volume30
Issue number1
DOIs
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Neuroscience(all)

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