TY - JOUR
T1 - GABA sets the tempo for activity-dependent adult neurogenesis
AU - Ge, Shaoyu
AU - Pradhan, Dennis A.
AU - Ming, Guo li
AU - Song, Hongjun
PY - 2007/1
Y1 - 2007/1
N2 - GABA, a major inhibitory neurotransmitter in the adult brain, activates synaptic and extrasynaptic GABAA receptors, causing hyperpolarization of mature neurons. As in the embryonic nervous system, GABA depolarizes neural progenitors and immature neurons in the adult brain. Several recent studies have suggested that GABA has crucial roles in regulating different steps of adult neurogenesis, including proliferation of neural progenitors, migration and differentiation of neuroblasts, and synaptic integration of newborn neurons. Here, we review recent findings on how GABA regulates adult neurogenesis in the subventricular zone of the lateral ventricles and in the dentate gyrus of the hippocampus. We also discuss an emerging view that GABA serves as a key mediator of neuronal activity in setting the tempo of adult neurogenesis.
AB - GABA, a major inhibitory neurotransmitter in the adult brain, activates synaptic and extrasynaptic GABAA receptors, causing hyperpolarization of mature neurons. As in the embryonic nervous system, GABA depolarizes neural progenitors and immature neurons in the adult brain. Several recent studies have suggested that GABA has crucial roles in regulating different steps of adult neurogenesis, including proliferation of neural progenitors, migration and differentiation of neuroblasts, and synaptic integration of newborn neurons. Here, we review recent findings on how GABA regulates adult neurogenesis in the subventricular zone of the lateral ventricles and in the dentate gyrus of the hippocampus. We also discuss an emerging view that GABA serves as a key mediator of neuronal activity in setting the tempo of adult neurogenesis.
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U2 - 10.1016/j.tins.2006.11.001
DO - 10.1016/j.tins.2006.11.001
M3 - Article
C2 - 17116335
AN - SCOPUS:33845787007
VL - 30
SP - 1
EP - 8
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 1
ER -