GABA regulates synaptic integration of newly generated neurons in the adult brain

Shaoyu Ge, Eyleen L K Goh, Kurt A. Sailor, Yasuji Kitabatake, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

Adult neurogenesis, the birth and integration of new neurons from adult neural stem cells, is a striking form of structural plasticity and highlights the regenerative capacity of the adult mammalian brain1-8. Accumulating evidence suggests that neuronal activity regulates adult neurogenesis and that new neurons contribute to specific brain functions 1-8. The mechanism that regulates the integration of newly generated neurons into the pre-existing functional circuitry in the adult brain is unknown. Here we show that newborn granule cells in the dentate gyrus of the adult hippocampus are tonically activated by ambient GABA (γ-aminobutyric acid) before being sequentially innervated by GABA- and glutamate-mediated synaptic inputs. GABA, the major inhibitory neurotransmitter in the adult brain, initially exerts an excitatory action on newborn neurons owing to their high cytoplasmic chloride ion content9-12. Conversion of GABA-induced depolarization (excitation) into hyperpolarization (inhibition) in newborn neurons leads to marked defects in their synapse formation and dendritic development in vivo. Our study identifies an essential role for GABA in the synaptic integration of newly generated neurons in the adult brain, and suggests an unexpected mechanism for activity-dependent regulation of adult neurogenesis, in which newborn neurons may sense neuronal network activity through tonic and phasic GABA activation.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalNature
Volume439
Issue number7076
DOIs
StatePublished - Feb 2 2006

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gamma-Aminobutyric Acid
Neurons
Brain
Neurogenesis
Aminobutyrates
Parahippocampal Gyrus
Adult Stem Cells
Neural Stem Cells
Dentate Gyrus
Synapses
Neurotransmitter Agents
Chlorides
Glutamic Acid
Parturition
Ions

ASJC Scopus subject areas

  • General

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Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G. L., & Song, H. (2006). GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature, 439(7076), 589-593. https://doi.org/10.1038/nature04404

GABA regulates synaptic integration of newly generated neurons in the adult brain. / Ge, Shaoyu; Goh, Eyleen L K; Sailor, Kurt A.; Kitabatake, Yasuji; Ming, Guo Li; Song, Hongjun.

In: Nature, Vol. 439, No. 7076, 02.02.2006, p. 589-593.

Research output: Contribution to journalArticle

Ge, S, Goh, ELK, Sailor, KA, Kitabatake, Y, Ming, GL & Song, H 2006, 'GABA regulates synaptic integration of newly generated neurons in the adult brain', Nature, vol. 439, no. 7076, pp. 589-593. https://doi.org/10.1038/nature04404
Ge S, Goh ELK, Sailor KA, Kitabatake Y, Ming GL, Song H. GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature. 2006 Feb 2;439(7076):589-593. https://doi.org/10.1038/nature04404
Ge, Shaoyu ; Goh, Eyleen L K ; Sailor, Kurt A. ; Kitabatake, Yasuji ; Ming, Guo Li ; Song, Hongjun. / GABA regulates synaptic integration of newly generated neurons in the adult brain. In: Nature. 2006 ; Vol. 439, No. 7076. pp. 589-593.
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