GABA receptors are increased in brains of alcoholics

Vinh T. Tran; Solomon H. Snyder; Leslie F. Major; Rollin J. Hawley

doi:10.1002/ana.410090312

GABA receptors are increased in brains of alcoholics

Vinh T. Tran, Solomon H. Snyder, Leslie F. Major, Rollin J. Hawley

School of Medicine

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

γ‐Aminobutyric acid (GABA) receptor binding was increased in postmortem brain samples of chronic alcoholic patients compared to control patients. Numbers of binding sites were augmented in alcoholic brain, with no change in affinity. Muscarinic cholinergic and benzodiazepine receptors did not differ between controls and alcoholic brains, while a modest reduction in β‐adrenergic receptors may have been related to postmortem receptor changes. The results suggest that GABA ergic mechanisms might play a role in chronic alcoholism.

Original language	English (US)
Pages (from-to)	289-292
Number of pages	4
Journal	Annals of neurology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1002/ana.410090312
State	Published - Mar 1981

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.410090312

Cite this

@article{a3128f4354e6411e85ec72702c969676,

title = "GABA receptors are increased in brains of alcoholics",

abstract = "γ‐Aminobutyric acid (GABA) receptor binding was increased in postmortem brain samples of chronic alcoholic patients compared to control patients. Numbers of binding sites were augmented in alcoholic brain, with no change in affinity. Muscarinic cholinergic and benzodiazepine receptors did not differ between controls and alcoholic brains, while a modest reduction in β‐adrenergic receptors may have been related to postmortem receptor changes. The results suggest that GABA ergic mechanisms might play a role in chronic alcoholism.",

author = "Tran, {Vinh T.} and Snyder, {Solomon H.} and Major, {Leslie F.} and Hawley, {Rollin J.}",

year = "1981",

month = mar,

doi = "10.1002/ana.410090312",

language = "English (US)",

volume = "9",

pages = "289--292",

journal = "Annals of neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - GABA receptors are increased in brains of alcoholics

AU - Tran, Vinh T.

AU - Snyder, Solomon H.

AU - Major, Leslie F.

AU - Hawley, Rollin J.

PY - 1981/3

Y1 - 1981/3

N2 - γ‐Aminobutyric acid (GABA) receptor binding was increased in postmortem brain samples of chronic alcoholic patients compared to control patients. Numbers of binding sites were augmented in alcoholic brain, with no change in affinity. Muscarinic cholinergic and benzodiazepine receptors did not differ between controls and alcoholic brains, while a modest reduction in β‐adrenergic receptors may have been related to postmortem receptor changes. The results suggest that GABA ergic mechanisms might play a role in chronic alcoholism.

AB - γ‐Aminobutyric acid (GABA) receptor binding was increased in postmortem brain samples of chronic alcoholic patients compared to control patients. Numbers of binding sites were augmented in alcoholic brain, with no change in affinity. Muscarinic cholinergic and benzodiazepine receptors did not differ between controls and alcoholic brains, while a modest reduction in β‐adrenergic receptors may have been related to postmortem receptor changes. The results suggest that GABA ergic mechanisms might play a role in chronic alcoholism.

UR - http://www.scopus.com/inward/record.url?scp=0019505073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019505073&partnerID=8YFLogxK

U2 - 10.1002/ana.410090312

DO - 10.1002/ana.410090312

M3 - Article

C2 - 6261673

AN - SCOPUS:0019505073

SN - 0364-5134

VL - 9

SP - 289

EP - 292

JO - Annals of neurology

JF - Annals of neurology

IS - 3

ER -

GABA receptors are increased in brains of alcoholics

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this