GABA receptors are increased in brains of alcoholics

Vinh T. Tran, Solomon H. Snyder, Leslie F. Major, Rollin J. Hawley

Research output: Contribution to journalArticlepeer-review

Abstract

γ‐Aminobutyric acid (GABA) receptor binding was increased in postmortem brain samples of chronic alcoholic patients compared to control patients. Numbers of binding sites were augmented in alcoholic brain, with no change in affinity. Muscarinic cholinergic and benzodiazepine receptors did not differ between controls and alcoholic brains, while a modest reduction in β‐adrenergic receptors may have been related to postmortem receptor changes. The results suggest that GABA ergic mechanisms might play a role in chronic alcoholism.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalAnnals of neurology
Volume9
Issue number3
DOIs
StatePublished - Mar 1981

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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