GABA levels in left and right sensorimotor cortex correlate across individuals

Nicolaas Puts, Stefanie Heba, Ashley D. Harris, Christopher John Evans, David J. McGonigle, Martin Tegenthoff, Tobias Schmidt-Wilcke, Richard Anthony Edward Edden

Research output: Contribution to journalArticle

Abstract

Differences in γ-aminobutyric acid (GABA) levels measured with Magnetic Resonance Spectroscopy have been shown to correlate with behavioral performance over a number of tasks and cortical regions. These correlations appear to be regionally and functionally specific. In this study, we test the hypothesis that GABA levels will be correlated within individuals for functionally related regions-the left and right sensorimotor cortex. In addition, we investigate whether this is driven by bulk tissue composition. GABA measurements using edited MRS data were acquired from the left and right sensorimotor cortex in 24 participants. T1-weighted MR images were also acquired and segmented to determine the tissue composition of the voxel. GABA level is shown to correlate significantly between the left and right regions (r = 0.64, p < 0.03). Tissue composition is highly correlated between sides, but does not explain significant variance in the bilateral correlation. In conclusion, individual differences in GABA level, which have previously been described as functionally and regionally specific, are correlated between homologous sensorimotor regions. This correlation is not driven by bulk differences in voxel tissue composition.

Original languageEnglish (US)
Article number80
JournalBiomedicines
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2018

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gamma-Aminobutyric Acid
Tissue
Chemical analysis
Magnetic resonance spectroscopy
Aminobutyrates
Individuality
Magnetic Resonance Spectroscopy
Sensorimotor Cortex

Keywords

  • Bilateral inhibition
  • GABA
  • Individual differences
  • MRS
  • Sensorimotor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

GABA levels in left and right sensorimotor cortex correlate across individuals. / Puts, Nicolaas; Heba, Stefanie; Harris, Ashley D.; Evans, Christopher John; McGonigle, David J.; Tegenthoff, Martin; Schmidt-Wilcke, Tobias; Edden, Richard Anthony Edward.

In: Biomedicines, Vol. 6, No. 3, 80, 01.09.2018.

Research output: Contribution to journalArticle

Puts, N, Heba, S, Harris, AD, Evans, CJ, McGonigle, DJ, Tegenthoff, M, Schmidt-Wilcke, T & Edden, RAE 2018, 'GABA levels in left and right sensorimotor cortex correlate across individuals', Biomedicines, vol. 6, no. 3, 80. https://doi.org/10.3390/biomedicines6030080
Puts, Nicolaas ; Heba, Stefanie ; Harris, Ashley D. ; Evans, Christopher John ; McGonigle, David J. ; Tegenthoff, Martin ; Schmidt-Wilcke, Tobias ; Edden, Richard Anthony Edward. / GABA levels in left and right sensorimotor cortex correlate across individuals. In: Biomedicines. 2018 ; Vol. 6, No. 3.
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