GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol

Joe Kelly, Jeffrey D Rothstein, Sebastian P. Grossman

Research output: Contribution to journalArticle

Abstract

Intrahypothalamic injections of the gamma-aminobutyric acid (GABA) agonist, muscimol (50 ng/μl), in volumes from 0.1 to 0.5 μl were made and the effects on feeding observed. The results of a topographical analysis of the hypothalamus indicated that both the paraventricular (PVH) and ventromedial (VMH) hypothalamic nuclei may be separate, though not necessarily independent, foci of a medial, GABA-sensitive satiety system. Microinjections of muscimol into these areas resulted in a dose-dependent increase in food intake. The effects of muscimol were blocked by local pretreatments with the GABA antagonist, bicuculline methiodide and behaviorally specific (water intake, in the absence of food was not affected). Opposite effects (suppression of feeding) were observed after muscimol injections into the region lateral to the fornix, suggesting that the excitatory lateral hypothalamic feeding system also may have GABAergic components.

Original languageEnglish (US)
Pages (from-to)1123-1134
Number of pages12
JournalPhysiology and Behavior
Volume23
Issue number6
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Muscimol
Microinjections
gamma-Aminobutyric Acid
Ventromedial Hypothalamic Nucleus
GABA Antagonists
GABA Agonists
Injections
Hypothalamus
Drinking
Eating
Food

Keywords

  • Bicuculline methiodide
  • GABA
  • Lateral hypothalamus
  • Muscimol
  • Paraventricular hypothalamus
  • Ventromedial hypothalamus

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol. / Kelly, Joe; Rothstein, Jeffrey D; Grossman, Sebastian P.

In: Physiology and Behavior, Vol. 23, No. 6, 1979, p. 1123-1134.

Research output: Contribution to journalArticle

@article{7c69623bc1914507bc0cff638cf775f5,
title = "GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol",
abstract = "Intrahypothalamic injections of the gamma-aminobutyric acid (GABA) agonist, muscimol (50 ng/μl), in volumes from 0.1 to 0.5 μl were made and the effects on feeding observed. The results of a topographical analysis of the hypothalamus indicated that both the paraventricular (PVH) and ventromedial (VMH) hypothalamic nuclei may be separate, though not necessarily independent, foci of a medial, GABA-sensitive satiety system. Microinjections of muscimol into these areas resulted in a dose-dependent increase in food intake. The effects of muscimol were blocked by local pretreatments with the GABA antagonist, bicuculline methiodide and behaviorally specific (water intake, in the absence of food was not affected). Opposite effects (suppression of feeding) were observed after muscimol injections into the region lateral to the fornix, suggesting that the excitatory lateral hypothalamic feeding system also may have GABAergic components.",
keywords = "Bicuculline methiodide, GABA, Lateral hypothalamus, Muscimol, Paraventricular hypothalamus, Ventromedial hypothalamus",
author = "Joe Kelly and Rothstein, {Jeffrey D} and Grossman, {Sebastian P.}",
year = "1979",
doi = "10.1016/0031-9384(79)90306-8",
language = "English (US)",
volume = "23",
pages = "1123--1134",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol

AU - Kelly, Joe

AU - Rothstein, Jeffrey D

AU - Grossman, Sebastian P.

PY - 1979

Y1 - 1979

N2 - Intrahypothalamic injections of the gamma-aminobutyric acid (GABA) agonist, muscimol (50 ng/μl), in volumes from 0.1 to 0.5 μl were made and the effects on feeding observed. The results of a topographical analysis of the hypothalamus indicated that both the paraventricular (PVH) and ventromedial (VMH) hypothalamic nuclei may be separate, though not necessarily independent, foci of a medial, GABA-sensitive satiety system. Microinjections of muscimol into these areas resulted in a dose-dependent increase in food intake. The effects of muscimol were blocked by local pretreatments with the GABA antagonist, bicuculline methiodide and behaviorally specific (water intake, in the absence of food was not affected). Opposite effects (suppression of feeding) were observed after muscimol injections into the region lateral to the fornix, suggesting that the excitatory lateral hypothalamic feeding system also may have GABAergic components.

AB - Intrahypothalamic injections of the gamma-aminobutyric acid (GABA) agonist, muscimol (50 ng/μl), in volumes from 0.1 to 0.5 μl were made and the effects on feeding observed. The results of a topographical analysis of the hypothalamus indicated that both the paraventricular (PVH) and ventromedial (VMH) hypothalamic nuclei may be separate, though not necessarily independent, foci of a medial, GABA-sensitive satiety system. Microinjections of muscimol into these areas resulted in a dose-dependent increase in food intake. The effects of muscimol were blocked by local pretreatments with the GABA antagonist, bicuculline methiodide and behaviorally specific (water intake, in the absence of food was not affected). Opposite effects (suppression of feeding) were observed after muscimol injections into the region lateral to the fornix, suggesting that the excitatory lateral hypothalamic feeding system also may have GABAergic components.

KW - Bicuculline methiodide

KW - GABA

KW - Lateral hypothalamus

KW - Muscimol

KW - Paraventricular hypothalamus

KW - Ventromedial hypothalamus

UR - http://www.scopus.com/inward/record.url?scp=0018591727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018591727&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(79)90306-8

DO - 10.1016/0031-9384(79)90306-8

M3 - Article

C2 - 542523

AN - SCOPUS:0018591727

VL - 23

SP - 1123

EP - 1134

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 6

ER -