Abstract
Intrahypothalamic injections of the gamma-aminobutyric acid (GABA) agonist, muscimol (50 ng/μl), in volumes from 0.1 to 0.5 μl were made and the effects on feeding observed. The results of a topographical analysis of the hypothalamus indicated that both the paraventricular (PVH) and ventromedial (VMH) hypothalamic nuclei may be separate, though not necessarily independent, foci of a medial, GABA-sensitive satiety system. Microinjections of muscimol into these areas resulted in a dose-dependent increase in food intake. The effects of muscimol were blocked by local pretreatments with the GABA antagonist, bicuculline methiodide and behaviorally specific (water intake, in the absence of food was not affected). Opposite effects (suppression of feeding) were observed after muscimol injections into the region lateral to the fornix, suggesting that the excitatory lateral hypothalamic feeding system also may have GABAergic components.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1123-1134 |
| Number of pages | 12 |
| Journal | Physiology and Behavior |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1979 |
| Externally published | Yes |
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Keywords
- Bicuculline methiodide
- GABA
- Lateral hypothalamus
- Muscimol
- Paraventricular hypothalamus
- Ventromedial hypothalamus
ASJC Scopus subject areas
- Physiology (medical)
- Behavioral Neuroscience
Cite this
GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol. / Kelly, Joe; Rothstein, Jeffrey D; Grossman, Sebastian P.
In: Physiology and Behavior, Vol. 23, No. 6, 1979, p. 1123-1134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol
AU - Kelly, Joe
AU - Rothstein, Jeffrey D
AU - Grossman, Sebastian P.
PY - 1979
Y1 - 1979
N2 - Intrahypothalamic injections of the gamma-aminobutyric acid (GABA) agonist, muscimol (50 ng/μl), in volumes from 0.1 to 0.5 μl were made and the effects on feeding observed. The results of a topographical analysis of the hypothalamus indicated that both the paraventricular (PVH) and ventromedial (VMH) hypothalamic nuclei may be separate, though not necessarily independent, foci of a medial, GABA-sensitive satiety system. Microinjections of muscimol into these areas resulted in a dose-dependent increase in food intake. The effects of muscimol were blocked by local pretreatments with the GABA antagonist, bicuculline methiodide and behaviorally specific (water intake, in the absence of food was not affected). Opposite effects (suppression of feeding) were observed after muscimol injections into the region lateral to the fornix, suggesting that the excitatory lateral hypothalamic feeding system also may have GABAergic components.
AB - Intrahypothalamic injections of the gamma-aminobutyric acid (GABA) agonist, muscimol (50 ng/μl), in volumes from 0.1 to 0.5 μl were made and the effects on feeding observed. The results of a topographical analysis of the hypothalamus indicated that both the paraventricular (PVH) and ventromedial (VMH) hypothalamic nuclei may be separate, though not necessarily independent, foci of a medial, GABA-sensitive satiety system. Microinjections of muscimol into these areas resulted in a dose-dependent increase in food intake. The effects of muscimol were blocked by local pretreatments with the GABA antagonist, bicuculline methiodide and behaviorally specific (water intake, in the absence of food was not affected). Opposite effects (suppression of feeding) were observed after muscimol injections into the region lateral to the fornix, suggesting that the excitatory lateral hypothalamic feeding system also may have GABAergic components.
KW - Bicuculline methiodide
KW - GABA
KW - Lateral hypothalamus
KW - Muscimol
KW - Paraventricular hypothalamus
KW - Ventromedial hypothalamus
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UR - http://www.scopus.com/inward/citedby.url?scp=0018591727&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(79)90306-8
DO - 10.1016/0031-9384(79)90306-8
M3 - Article
C2 - 542523
AN - SCOPUS:0018591727
VL - 23
SP - 1123
EP - 1134
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 6
ER -