GABA and glutamate in children with primary complex motor stereotypies

An 1H-MRS study at 7T

A. D. Harris, Harvey Singer, A. Horska, T. Kline, M. Ryan, Richard Anthony Edward Edden, Ernest M Mahone

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Complex motor stereotypies are rhythmic, repetitive, fixed, purposeful but purposeless movements that stop with distraction. They can occur in otherwise normal healthy children (primary stereotypies) as well in those with autism spectrum disorders (secondary stereotypies). The underlying neurobiologic basis for these movements is unknown but is thought to involve cortical-striatal-thalamo-cortical pathways. To further clarify potential neurochemical alterations, gamma-aminobutyric acid (GABA), glutamate, glutamine, N-acetylaspartate, and choline levels were measured in 4 frontostriatal regions by using 1H MRS at 7T. MATERIALS AND METHODS: A total of 18 children with primary complex motor stereotypies and 24 typically developing controls, ages 5-10 years, completed MR spectroscopy at 7T. Single voxel STEAM acquisitions from the anterior cingulate cortex, premotor cortex, dorsolateral prefrontal cortex, and striatum were obtained, and metabolites were quantified with respect to Cr by using LCModel. RESULTS: The 7T scan was well tolerated by all the participants. Compared with the controls, children with complex motor stereotypies had lower levels of GABA in the anterior cingulate cortex (GABA/Cr, P =.049; GABA/Glu, P =.051) and striatum (GABA/Cr, P =.028; GABA/Glu, P =.0037) but not the dorsolateral prefrontal cortex or the premotor cortex. Glutamate, glutamine, NAA, and Cho levels did not differ between groups in any of the aforementioned regions. Within the complex motor stereotypies group, reduced GABA to Cr in the anterior cingulate cortex was significantly associated with greater severity of motor stereotypies (r=-0.59, P =.021). CONCLUSIONS: These results indicate possible GABAergic dysfunction within corticostriatal pathways in children with primary complex motor stereotypies.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume37
Issue number3
DOIs
StatePublished - Mar 1 2016

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gamma-Aminobutyric Acid
Glutamic Acid
Gyrus Cinguli
Motor Cortex
Prefrontal Cortex
Glutamine
Corpus Striatum
Choline
Proton Magnetic Resonance Spectroscopy
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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GABA and glutamate in children with primary complex motor stereotypies : An 1H-MRS study at 7T. / Harris, A. D.; Singer, Harvey; Horska, A.; Kline, T.; Ryan, M.; Edden, Richard Anthony Edward; Mahone, Ernest M.

In: American Journal of Neuroradiology, Vol. 37, No. 3, 01.03.2016, p. 552-557.

Research output: Contribution to journalArticle

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