G-quadruplex DNA bound by a synthetic ligand is highly dynamic

Prakrit V. Jena, Pravin S. Shirude, Burak Okumus, Katta Laxmi-Reddy, Frédéric Godde, Ivan Huc, Shankar Balasubramanian, Taekjip Ha

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Using single molecule fluorescence resonance energy transfer, we investigated the interaction between a quadruplex-binding ligand and the human telomeric G-quadruplex. The binding of quinolinecarboxamide macrocycle to telomeric DNA was essentially irreversible and selectively induced and favored one quadruplex conformation. The ligand-quadruplex complex displayed intramolecular dynamics including quadruplex folding and unfolding in the absence of ligand association and dissociation. We report that the G-quadruplex can be stabilized without preventing the intrinsic intramolecular dynamics of telomeric DNA.

Original languageEnglish (US)
Pages (from-to)12522-12523
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number35
DOIs
StatePublished - Sep 9 2009
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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