G proteins and olfactory signal transduction

Gabriele V. Ronnett, Cheil Moon

Research output: Contribution to journalArticlepeer-review

Abstract

The olfactory system sits at the interface of the environment and the nervous system and is responsible for correctly coding sensory information from thousands of odorous stimuli. Many theories existed regarding the signal transduction mechanism that mediates this difficult task. The discovery that odorant transduction utilizes a unique variation (a novel family of G protein-coupled receptors) based upon a very common theme (the G protein-coupled adenylyl cyclase cascade) to accomplish its vital task emphasized the power and versatility of this motif. We now must understand the downstream consequences of this cascade that regulates multiple second messengers and perhaps even gene transcription in response to the inifial interaction of ligand with G protein-coupled receptor.

Original languageEnglish (US)
Pages (from-to)189-222
Number of pages34
JournalAnnual Review of Physiology
Volume64
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Adenylyl cyclase
  • Cross-talk
  • Desensitization
  • Olfaction
  • Olfactory receptor neuron
  • Second messengers
  • Sensory transduction

ASJC Scopus subject areas

  • Physiology

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