G protein-coupled receptors in gastrointestinal physiology III. Asymmetry in plasma membrane signal transduction

Lessons from brush-border Na+/H+ exchangers

Mark Donowitz, S. Khurana, Chung Ming Tse, C. H C Yun

Research output: Contribution to journalArticle

Abstract

Signal transduction in epithelial cells adds another level of complexity to the signaling that occurs in symmetrical cells, in the form of the need to coordinate and keep separate signals at the apical and basolateral membranes. Regulation by protein kinases of ileal NaCl absorption and its component brush-border Na+/H+ exchanger are used as an example of how signaling in epithelial cells must deal with spatial localization of signals, protein- protein interactions, signaling molecules, and the involvement of the transport protein being regulated in collecting and focusing the signals generated at the receptor and beyond.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume274
Issue number6 37-6
StatePublished - Jun 1998

Fingerprint

Sodium-Hydrogen Antiporter
Microvilli
G-Protein-Coupled Receptors
Signal Transduction
Epithelial Cells
Cell Membrane
Protein Kinases
Carrier Proteins
Proteins
Membranes

Keywords

  • Carbachol
  • Epidermal growth factor
  • Intestinal epithelial cells
  • NHE3
  • Signalosomes

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Physiology (medical)

Cite this

@article{8b88d6dceefd43abb9780b0df3a72b81,
title = "G protein-coupled receptors in gastrointestinal physiology III. Asymmetry in plasma membrane signal transduction: Lessons from brush-border Na+/H+ exchangers",
abstract = "Signal transduction in epithelial cells adds another level of complexity to the signaling that occurs in symmetrical cells, in the form of the need to coordinate and keep separate signals at the apical and basolateral membranes. Regulation by protein kinases of ileal NaCl absorption and its component brush-border Na+/H+ exchanger are used as an example of how signaling in epithelial cells must deal with spatial localization of signals, protein- protein interactions, signaling molecules, and the involvement of the transport protein being regulated in collecting and focusing the signals generated at the receptor and beyond.",
keywords = "Carbachol, Epidermal growth factor, Intestinal epithelial cells, NHE3, Signalosomes",
author = "Mark Donowitz and S. Khurana and Tse, {Chung Ming} and Yun, {C. H C}",
year = "1998",
month = "6",
language = "English (US)",
volume = "274",
journal = "American Journal of Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "6 37-6",

}

TY - JOUR

T1 - G protein-coupled receptors in gastrointestinal physiology III. Asymmetry in plasma membrane signal transduction

T2 - Lessons from brush-border Na+/H+ exchangers

AU - Donowitz, Mark

AU - Khurana, S.

AU - Tse, Chung Ming

AU - Yun, C. H C

PY - 1998/6

Y1 - 1998/6

N2 - Signal transduction in epithelial cells adds another level of complexity to the signaling that occurs in symmetrical cells, in the form of the need to coordinate and keep separate signals at the apical and basolateral membranes. Regulation by protein kinases of ileal NaCl absorption and its component brush-border Na+/H+ exchanger are used as an example of how signaling in epithelial cells must deal with spatial localization of signals, protein- protein interactions, signaling molecules, and the involvement of the transport protein being regulated in collecting and focusing the signals generated at the receptor and beyond.

AB - Signal transduction in epithelial cells adds another level of complexity to the signaling that occurs in symmetrical cells, in the form of the need to coordinate and keep separate signals at the apical and basolateral membranes. Regulation by protein kinases of ileal NaCl absorption and its component brush-border Na+/H+ exchanger are used as an example of how signaling in epithelial cells must deal with spatial localization of signals, protein- protein interactions, signaling molecules, and the involvement of the transport protein being regulated in collecting and focusing the signals generated at the receptor and beyond.

KW - Carbachol

KW - Epidermal growth factor

KW - Intestinal epithelial cells

KW - NHE3

KW - Signalosomes

UR - http://www.scopus.com/inward/record.url?scp=0031798960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031798960&partnerID=8YFLogxK

M3 - Article

VL - 274

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 6 37-6

ER -