Future Tox III: Bridges for translation

Daland R. Juberg, Thomas B. Knudsen, Miriam Sander, Nancy B. Beck, Elaine M. Faustman, Donna L. Mendrick, John R. Fowle, Thomas Hartung, Raymond R. Tice, Emmanuel Lemazurier, Richard A. Becker, Suzanne Compton Fitzpatrick, George P. Daston, Alison Harrill, Ronald N. Hines, Douglas A. Keller, John C. Lipscomb, David Watson, Tina Bahadori, Kevin M. Crofton

Research output: Contribution to journalArticle

Abstract

Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalToxicological Sciences
Volume155
Issue number1
DOIs
StatePublished - 2017

Keywords

  • In vitro and alternatives
  • Predictive toxicology
  • Regulatory/policy
  • Risk assessment
  • Testing alternatives

ASJC Scopus subject areas

  • Toxicology

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    Juberg, D. R., Knudsen, T. B., Sander, M., Beck, N. B., Faustman, E. M., Mendrick, D. L., Fowle, J. R., Hartung, T., Tice, R. R., Lemazurier, E., Becker, R. A., Fitzpatrick, S. C., Daston, G. P., Harrill, A., Hines, R. N., Keller, D. A., Lipscomb, J. C., Watson, D., Bahadori, T., & Crofton, K. M. (2017). Future Tox III: Bridges for translation. Toxicological Sciences, 155(1), 22-31. https://doi.org/10.1093/toxsci/kfw194