Future directions for cardiovascular disease comparative effectiveness research: Report of a workshop sponsored by the national heart, lung, and blood institute

Mark A. Hlatky, Pamela S. Douglas, Nakela L. Cook, Barbara Wells, Emelia J. Benjamin, Kay Dickersin, David C. Goff, Alan T. Hirsch, Elaine M. Hylek, Eric D. Peterson, Véronique L. Roger, Joseph V. Selby, James E. Udelson, Michael S. Lauer

Research output: Contribution to journalArticle


Comparative effectiveness research (CER) aims to provide decision makers with the evidence needed to evaluate the benefits and harms of alternative clinical management strategies. CER has become a national priority, with considerable new research funding allocated. Cardiovascular disease is a priority area for CER. This workshop report provides an overview of CER methods, with an emphasis on practical clinical trials and observational treatment comparisons. The report also details recommendations to the National Heart, Lung, and Blood Institute for a new framework for evidence development to foster cardiovascular CER, and specific studies to address 8 clinical issues identified by the Institute of Medicine as high priorities for cardiovascular CER.

Original languageEnglish (US)
Pages (from-to)569-580
Number of pages12
JournalJournal of the American College of Cardiology
Issue number7
Publication statusPublished - Aug 14 2012



  • clinical trials
  • comparative effectiveness
  • research methods

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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