Fusion of multisubject hemodynamic and event-related potential data using independent component analysis

V. Calhoun, T. Adah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional magnetic resonance imaging (fMRI) data provides spatially localized subcentimeter information about blood flow and oxygenation secondary to neuronal activation, but with temporal resolution on the order of seconds. Event-related potential (ERP) studies provide millimeter resolution measurements of the electric changes induced by neuronal activity, but spatial information is not well localized and suffers from an ill-posed inverse problem since there are much fewer sensors than solutions. Combining or fusing these two techniques thus has the potential to provide simultaneous higher temporal and high spatial resolution. Localization of the brain's response to infrequent, task-relevant target 'oddball' stimuli in humans has remained challenging due to the lack of a single imaging technique with good spatial and temporal resolution. In this paper, we use independent component analysis to fuse ERP and fMRI modalities to identify, for the first time in humans, the dynamics of the auditory oddball response with high spatiotemporal resolution across the entire brain. The results illuminate a new era of brain research utilizing the precise temporal information in ERPs and the high spatial resolution of fMRI.

Original languageEnglish (US)
Title of host publication2006 IEEE International Conference on Acoustics, Speech, and Signal Processing - Proceedings
PagesV1113-V1116
StatePublished - Dec 1 2006
Externally publishedYes
Event2006 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP 2006 - Toulouse, France
Duration: May 14 2006May 19 2006

Publication series

NameICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
Volume5
ISSN (Print)1520-6149

Other

Other2006 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP 2006
CountryFrance
CityToulouse
Period5/14/065/19/06

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Electrical and Electronic Engineering

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