Fusarium infection in hematopoietic stem cell transplant recipients

Marcio Nucci; Kieren A. Marr; Flavio Queiroz-Telles; Carlos A. Martins; Plínio Trabasso; Silvia Costa; Julio C. Voltarelli; Arnaldo L. Colombo; Alexander Imhof; Ricardo Pasquini; Angelo Maiolino; Cármino A. Souza; Elias Anaissie

doi:10.1086/383319

Fusarium infection in hematopoietic stem cell transplant recipients

Marcio Nucci, Kieren A. Marr, Flavio Queiroz-Telles, Carlos A. Martins, Plínio Trabasso, Silvia Costa, Julio C. Voltarelli, Arnaldo L. Colombo, Alexander Imhof, Ricardo Pasquini, Angelo Maiolino, Cármino A. Souza, Elias Anaissie

Research output: Contribution to journal › Review article › peer-review

241 Scopus citations

Abstract

To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA) - matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.

Original language	English (US)
Pages (from-to)	1237-1242
Number of pages	6
Journal	Clinical Infectious Diseases
Volume	38
Issue number	9
DOIs	https://doi.org/10.1086/383319
State	Published - May 1 2004
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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@article{13bc985da525454abfdfcbda1b635de2,

title = "Fusarium infection in hematopoietic stem cell transplant recipients",

abstract = "To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA) - matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.",

author = "Marcio Nucci and Marr, {Kieren A.} and Flavio Queiroz-Telles and Martins, {Carlos A.} and Pl{\'i}nio Trabasso and Silvia Costa and Voltarelli, {Julio C.} and Colombo, {Arnaldo L.} and Alexander Imhof and Ricardo Pasquini and Angelo Maiolino and Souza, {C{\'a}rmino A.} and Elias Anaissie",

note = "Funding Information: Financial support: Conselho Nacional de Pesquisa, Brazil (grant 300235/93-3).",

year = "2004",

month = may,

day = "1",

doi = "10.1086/383319",

language = "English (US)",

volume = "38",

pages = "1237--1242",

journal = "Clinical Infectious Diseases",

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TY - JOUR

T1 - Fusarium infection in hematopoietic stem cell transplant recipients

AU - Nucci, Marcio

AU - Marr, Kieren A.

AU - Queiroz-Telles, Flavio

AU - Martins, Carlos A.

AU - Trabasso, Plínio

AU - Costa, Silvia

AU - Voltarelli, Julio C.

AU - Colombo, Arnaldo L.

AU - Imhof, Alexander

AU - Pasquini, Ricardo

AU - Maiolino, Angelo

AU - Souza, Cármino A.

AU - Anaissie, Elias

N1 - Funding Information: Financial support: Conselho Nacional de Pesquisa, Brazil (grant 300235/93-3).

PY - 2004/5/1

Y1 - 2004/5/1

N2 - To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA) - matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.

AB - To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA) - matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.

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DO - 10.1086/383319

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SP - 1237

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JO - Clinical Infectious Diseases

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Fusarium infection in hematopoietic stem cell transplant recipients

Abstract

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