Fusarium infection in hematopoietic stem cell transplant recipients

Marcio Nucci, Kieren A. Marr, Flavio Queiroz-Telles, Carlos A. Martins, Plínio Trabasso, Silvia Costa, Julio C. Voltarelli, Arnaldo L. Colombo, Alexander Imhof, Ricardo Pasquini, Angelo Maiolino, Cármino A. Souza, Elias Anaissie

Research output: Contribution to journalReview article

Abstract

To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA) - matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.

Original languageEnglish (US)
Pages (from-to)1237-1242
Number of pages6
JournalClinical Infectious Diseases
Volume38
Issue number9
DOIs
StatePublished - May 1 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Nucci, M., Marr, K. A., Queiroz-Telles, F., Martins, C. A., Trabasso, P., Costa, S., Voltarelli, J. C., Colombo, A. L., Imhof, A., Pasquini, R., Maiolino, A., Souza, C. A., & Anaissie, E. (2004). Fusarium infection in hematopoietic stem cell transplant recipients. Clinical Infectious Diseases, 38(9), 1237-1242. https://doi.org/10.1086/383319