TY - JOUR
T1 - Further Studies on Release of Serotonin and Histamine During Anaphylaxis in the Rabbit
AU - Waalkes, T. Phillip
AU - Weissbach, Herbert
AU - Bozicevich, John
AU - Udenfriend, Sidney
PY - 1957/7
Y1 - 1957/7
N2 - 1. Reserpine injected intravenously into rabbits in the amount of 0.1 mg/kg causes a marked lowering of platelet serotonin and histamine without reducing serotonin or histamine in the intestinal tract below the normal range. 2. Sensitized rabbits, pretreated with 0.1 mg/kg of reserpine, had an elevated plasma level of histamine but not of serotonin during anaphylaxis. These findings suggest that the major portion of the rise in plasma serotonin during anaphylaxis is secondary to a release from platelets, whereas the histamine found in the plasma is probably released both from platelets and tissues. In rabbits that had been pretreated with 5 mg/kg of reserpine, histamine levels in the plasma during anaphylaxis were still elevated. 3. The significance of levels attained in the plasma as an index of release from tissues during anaphylaxis is discussed.
AB - 1. Reserpine injected intravenously into rabbits in the amount of 0.1 mg/kg causes a marked lowering of platelet serotonin and histamine without reducing serotonin or histamine in the intestinal tract below the normal range. 2. Sensitized rabbits, pretreated with 0.1 mg/kg of reserpine, had an elevated plasma level of histamine but not of serotonin during anaphylaxis. These findings suggest that the major portion of the rise in plasma serotonin during anaphylaxis is secondary to a release from platelets, whereas the histamine found in the plasma is probably released both from platelets and tissues. In rabbits that had been pretreated with 5 mg/kg of reserpine, histamine levels in the plasma during anaphylaxis were still elevated. 3. The significance of levels attained in the plasma as an index of release from tissues during anaphylaxis is discussed.
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U2 - 10.3181/00379727-95-23258
DO - 10.3181/00379727-95-23258
M3 - Article
C2 - 13453475
AN - SCOPUS:84910992194
SN - 0037-9727
VL - 95
SP - 479
EP - 482
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 3
ER -