@article{3b2f144945ce4d12a3ad1126627ed973,
title = "Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans",
abstract = "Background: Genome-wide association studies of asthma have implicated many genetic risk factors, with well-replicated associations at approximately 10 loci that account for only a small proportion of the genetic risk. Objectives: We aimed to identify additional asthma risk loci by performing an extensive replication study of the results from the EVE Consortium meta-analysis. Methods: We selected 3186 single nucleotide polymorphisms for replication based on the P values from the EVE Consortium meta-analysis. These single nucleotide polymorphisms were genotyped in ethnically diverse replication samples from 9 different studies, totaling 7202 cases, 6426 controls, and 507 case-parent trios. Association analyses were conducted within each participating study, and the resulting test statistics were combined in a meta-analysis. Results: Two novel associations were replicated in European Americans: rs1061477 in the KLK3 gene on chromosome 19 (combined odds ratio = 1.18; 95% CI, 1.10-1.25) and rs9570077 (combined odds ratio =1.20; 95% CI, 1.12-1.29) on chromosome 13q21. We could not replicate any additional associations in the African Americans or Latinos. Conclusions: This extended replication study identified 2 additional asthma risk loci in populations of European descent. The absence of additional loci for African Americans and Latinos highlights the difficulty in replicating associations in admixed populations.",
keywords = "Asthma, KLK3, genetic risk factors, meta-analysis",
author = "Myers, {Rachel A.} and Himes, {Blanca E.} and Gignoux, {Christopher R.} and Yang, {James J.} and Gauderman, {W. James} and Cristina Rebordosa and Jianming Xie and Torgerson, {Dara G.} and Levin, {Albert M.} and James Baurley and Graves, {Penelope E.} and Mathias, {Rasika A.} and Isabelle Romieu and Roth, {Lindsey A.} and David Conti and Lydiana Avila and Celeste Eng and Hita Vora and Lenoir, {Michael A.} and Manuel Soto-Quiros and Jinghua Liu and Celed{\'o}n, {Juan C.} and Farber, {Harold J.} and Rajesh Kumar and Avila, {Pedro C.} and Kelley Meade and Denise Serebrisky and Shannon Thyne and William Rodriguez-Cintron and Rodriguez-Santana, {Jose R.} and Borrell, {Luisa N.} and Lemanske, {Robert F.} and Bleecker, {Eugene R.} and Meyers, {Deborah A.} and London, {Stephanie J.} and Barnes, {Kathleen C.} and Raby, {Benjamin A.} and Martinez, {Fernando D.} and Gilliland, {Frank D.} and Williams, {L. Keoki} and Burchard, {Esteban G.} and Weiss, {Scott T.} and Nicolae, {Dan L.} and Carole Ober",
note = "Funding Information: Supported by grants from the Office of the Director, National Institutes of Health (NIH) to C.O. and D.L.N.; the National Heart, Lung, and Blood Institute ( HL101651 to C.O. and D.L.N.; HL087665 to D.L.N.; HL070831 , HL072414 , and HL049596 to C.O.; HL064307 and HL064313 to F.D.M.; HL075419 , HL65899 , HL083069 , HL066289 , HL087680 , HL101543 , and HL101651 to S.T.W.; HL079055 to L.K.W.; HL087699 , HL49612 , HL075417 , HL04266 , and HL072433 to K.C.B.; HL061768 and HL076647 to F.D.G.; HL087680 to W.J.G.; HL078885 and HL088133 to E.G.B.; and HL87665 to D.A.M.); the National Institutes of Allergy and Infectious Disease ( AI070503 to C.O.; AI079139 and AI061774 to L.K.W.; AI50024 , AI44840 , and AI41040 to K.C.B.; and AI077439 to E.G.B.); the National Institute of Diabetes and Digestive and Kidney Diseases to L.K.W. ( DK064695 ); the National Institutes of Environmental Health Sciences ( ES09606 , ES018176 , and ES015903 to K.C.B.; ES007048 , ES009581 , R826708 , RD831861 , and ES011627 to F.D.G.; ES015794 to E.G.B.; and the Division of Intramural Research, Z01 ES049019 to S.J.L.); the National Center for Research Resources ( RR03048 to K.C.B., RR00188 to H.J.F.); the Environmental Protection Agency ( 83213901 and R-826724 to K.C.B.); the American Asthma Foundation and the Fund for Henry Ford Hospital (to L.K.W.); Mary Beryl Patch Turnbull Scholar Program (to K.C.B.); and the Flight Attendant Medical Research Institute (FAMRI), Robert Wood Johnson Foundation (RWJF) Amos Medical Faculty Development Award, the American Asthma Foundation, and the Sandler Foundation (to E.G.B.). ",
year = "2012",
month = dec,
doi = "10.1016/j.jaci.2012.07.054",
language = "English (US)",
volume = "130",
pages = "1294--1301",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "6",
}