Further investigation on the radiosynthesis of α‐[11C]methyl‐tryptophan

Makiko Suehiro, Hayden T. Ravert, Alan A. Wilson, Ursula Scheffel, Robert F. Dannals, Henry N. Wagner

Research output: Contribution to journalComment/debatepeer-review

Abstract

Improved procedures for the radiosynthesis of α‐[11C]methyltryptophan and α‐[11C]methyl‐tryptophan methyl ester were studied. Following α‐deprotonation of tryptophan methyl ester benzaldimine with LDA, 60 – 80% of no carrier added [11C]iodomethane was incorporated in 5 minutes at 27 – 30°C. After HPLC purification, radiochemically pure α‐[11C]methyl‐tryptophan or its methyl ester was produced with minimum chemical contamination from tryptophan. The [11C]methyl‐tryptophan synthesized, however, was found to be a racemate.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume31
Issue number2
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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