Further evidence that infection is an infrequent cause of first trimester spontaneous abortion

Joe Leigh Simpson, Ronald H Gray, John T. Queenan, Michele Barbato, Alfredo Perez, Patricio Mena, Robert T. Kambic, Francisco Pardo, Wilma Stevenson, Chunjun Li, Victoria Jennings

Research output: Contribution to journalArticle

Abstract

A previous cohort study found no clinical evidence that infection occurred more often in subjects experiencing pregnancy loss compared with those experiencing successful pregnancy. Given these surprising findings, we conducted a similar analysis on another cohort also followed prospectively. Using couples practising natural family planning for conception or contraception, information on clinical evidence of infection was gathered beginning with week 5 of gestation. Information on fever and signs of overt infection was specifically sought by interview and physical examination. Frequencies of urinary, vaginal and other infections in subjects experiencing pregnancy loss were 11.1, 9.5 and 8.7% respectively, not significantly different from rates in subjects having liveborns (10.1, 10.2 and 10.3% respectively). Thus, no association between clinical infection and early pregnancy loss (≤ 16 weeks) was observed. Cohort studies utilizing biologically based assays are awaited because extant data do not provide evidence that clinically evident infections play major roles in first trimester pregnancy losses.

Original languageEnglish (US)
Pages (from-to)2058-2060
Number of pages3
JournalHuman Reproduction
Volume11
Issue number9
StatePublished - Sep 1996

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Spontaneous Abortion
First Pregnancy Trimester
Pregnancy
Infection
Cohort Studies
Natural Family Planning Methods
Contraception
Physical Examination
Fever
Interviews

Keywords

  • First trimester
  • Infections
  • Spontaneous abortion

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Simpson, J. L., Gray, R. H., Queenan, J. T., Barbato, M., Perez, A., Mena, P., ... Jennings, V. (1996). Further evidence that infection is an infrequent cause of first trimester spontaneous abortion. Human Reproduction, 11(9), 2058-2060.

Further evidence that infection is an infrequent cause of first trimester spontaneous abortion. / Simpson, Joe Leigh; Gray, Ronald H; Queenan, John T.; Barbato, Michele; Perez, Alfredo; Mena, Patricio; Kambic, Robert T.; Pardo, Francisco; Stevenson, Wilma; Li, Chunjun; Jennings, Victoria.

In: Human Reproduction, Vol. 11, No. 9, 09.1996, p. 2058-2060.

Research output: Contribution to journalArticle

Simpson, JL, Gray, RH, Queenan, JT, Barbato, M, Perez, A, Mena, P, Kambic, RT, Pardo, F, Stevenson, W, Li, C & Jennings, V 1996, 'Further evidence that infection is an infrequent cause of first trimester spontaneous abortion', Human Reproduction, vol. 11, no. 9, pp. 2058-2060.
Simpson JL, Gray RH, Queenan JT, Barbato M, Perez A, Mena P et al. Further evidence that infection is an infrequent cause of first trimester spontaneous abortion. Human Reproduction. 1996 Sep;11(9):2058-2060.
Simpson, Joe Leigh ; Gray, Ronald H ; Queenan, John T. ; Barbato, Michele ; Perez, Alfredo ; Mena, Patricio ; Kambic, Robert T. ; Pardo, Francisco ; Stevenson, Wilma ; Li, Chunjun ; Jennings, Victoria. / Further evidence that infection is an infrequent cause of first trimester spontaneous abortion. In: Human Reproduction. 1996 ; Vol. 11, No. 9. pp. 2058-2060.
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