Further evidence supporting the association of NKAPL with schizophrenia

Zhiqiang Wang, Bixiu Yang, Yansong Liu, Yin Yao Shugart, Zaohuo Cheng, Chunhui Jin, Jianmin Yuan, Wei Zhu, Guoqiang Wang, Fuquan Zhang

Research output: Contribution to journalArticle

Abstract

Schizophrenia (SZ) is a severe chronic mental disorder with complex genetic mechanismsIncreasing evidence implicate immune system dysfunction in the pathogenesis of SZThe non-synonymous single nucleotide polymorphism (SNP) rs1635 in NKAPL, was identified by a genome-wide association study (GWAS) for SZ in Han Chinese from north ChinaA replication study failed to detect the association of rs1635 with SZ in Han Chinese from central south of China, while another one confirmed the positive association in Han Chinese from TaiwanTo further clarify these findings, we conducted a case-control association study of rs1635 in a cohort of Han Chinese from east China, including 1406 SZ cases and 1136 healthy controlsWe detected a positive association of rs1635 with SZ, with the major allele (G) of rs1635 conferring a risk for SZ (P=0.033, OR=1.14)Our findings add further evidence for the involvement of NKAPL polymorphisms in the development of SZ

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Volume605
DOIs
StatePublished - Sep 25 2015
Externally publishedYes

Keywords

  • NKAPL
  • rs1635
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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  • Cite this

    Wang, Z., Yang, B., Liu, Y., Shugart, Y. Y., Cheng, Z., Jin, C., Yuan, J., Zhu, W., Wang, G., & Zhang, F. (2015). Further evidence supporting the association of NKAPL with schizophrenia. Neuroscience Letters, 605, 49-52. https://doi.org/10.1016/j.neulet.2015.08.023