Further evidence for location of the spherocytosis gene on chromosome 8

Eric B Bass, S. W. Smith, R. E. Stevenson, W. F. Rosse

Research output: Contribution to journalArticle

Abstract

Hereditary spherocytosis (HS) is a form of hemolytic anemia transmitted as an autosomal dominant trait. To date, the HS gene has not been mapped to a specific chromosome. Kimberling and associates reported a family containing 14 members with both HS and a balanced translocation between the short arms of chromosomes 8 and 12 (t(8;12) (p11; p13). This linkage between hereditary spherocytosis and the translocation would place the HS locus on chromosome 8 or chromosome 12. We report a mother and son with hereditary spherocytosis and a balanced translocation between chromosomes 3 and 8 and suggest that the HS gene is on chromosome 8.

Original languageEnglish (US)
Pages (from-to)192-193
Number of pages2
JournalAnnals of Internal Medicine
Volume99
Issue number2
StatePublished - 1983
Externally publishedYes

Fingerprint

Hereditary Spherocytosis
Chromosomes, Human, Pair 8
Genes
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 3
Hemolytic Anemia
Chromosomes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bass, E. B., Smith, S. W., Stevenson, R. E., & Rosse, W. F. (1983). Further evidence for location of the spherocytosis gene on chromosome 8. Annals of Internal Medicine, 99(2), 192-193.

Further evidence for location of the spherocytosis gene on chromosome 8. / Bass, Eric B; Smith, S. W.; Stevenson, R. E.; Rosse, W. F.

In: Annals of Internal Medicine, Vol. 99, No. 2, 1983, p. 192-193.

Research output: Contribution to journalArticle

Bass, EB, Smith, SW, Stevenson, RE & Rosse, WF 1983, 'Further evidence for location of the spherocytosis gene on chromosome 8', Annals of Internal Medicine, vol. 99, no. 2, pp. 192-193.
Bass, Eric B ; Smith, S. W. ; Stevenson, R. E. ; Rosse, W. F. / Further evidence for location of the spherocytosis gene on chromosome 8. In: Annals of Internal Medicine. 1983 ; Vol. 99, No. 2. pp. 192-193.
@article{e0bd8672220b4b66a78dbf8923d760f8,
title = "Further evidence for location of the spherocytosis gene on chromosome 8",
abstract = "Hereditary spherocytosis (HS) is a form of hemolytic anemia transmitted as an autosomal dominant trait. To date, the HS gene has not been mapped to a specific chromosome. Kimberling and associates reported a family containing 14 members with both HS and a balanced translocation between the short arms of chromosomes 8 and 12 (t(8;12) (p11; p13). This linkage between hereditary spherocytosis and the translocation would place the HS locus on chromosome 8 or chromosome 12. We report a mother and son with hereditary spherocytosis and a balanced translocation between chromosomes 3 and 8 and suggest that the HS gene is on chromosome 8.",
author = "Bass, {Eric B} and Smith, {S. W.} and Stevenson, {R. E.} and Rosse, {W. F.}",
year = "1983",
language = "English (US)",
volume = "99",
pages = "192--193",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "2",

}

TY - JOUR

T1 - Further evidence for location of the spherocytosis gene on chromosome 8

AU - Bass, Eric B

AU - Smith, S. W.

AU - Stevenson, R. E.

AU - Rosse, W. F.

PY - 1983

Y1 - 1983

N2 - Hereditary spherocytosis (HS) is a form of hemolytic anemia transmitted as an autosomal dominant trait. To date, the HS gene has not been mapped to a specific chromosome. Kimberling and associates reported a family containing 14 members with both HS and a balanced translocation between the short arms of chromosomes 8 and 12 (t(8;12) (p11; p13). This linkage between hereditary spherocytosis and the translocation would place the HS locus on chromosome 8 or chromosome 12. We report a mother and son with hereditary spherocytosis and a balanced translocation between chromosomes 3 and 8 and suggest that the HS gene is on chromosome 8.

AB - Hereditary spherocytosis (HS) is a form of hemolytic anemia transmitted as an autosomal dominant trait. To date, the HS gene has not been mapped to a specific chromosome. Kimberling and associates reported a family containing 14 members with both HS and a balanced translocation between the short arms of chromosomes 8 and 12 (t(8;12) (p11; p13). This linkage between hereditary spherocytosis and the translocation would place the HS locus on chromosome 8 or chromosome 12. We report a mother and son with hereditary spherocytosis and a balanced translocation between chromosomes 3 and 8 and suggest that the HS gene is on chromosome 8.

UR - http://www.scopus.com/inward/record.url?scp=0020955840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020955840&partnerID=8YFLogxK

M3 - Article

C2 - 6881776

AN - SCOPUS:0020955840

VL - 99

SP - 192

EP - 193

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 2

ER -