Further Evidence for Dementia of the Prefrontal Type in Schizophrenia? A Controlled Study of Teaching the Wisconsin Card Sorting Test

Terry E. Goldberg, Daniel R. Weinberger, Karen Faith Berman, Neil H. Pliskin, Marvin H. Podd

Research output: Contribution to journalArticle

Abstract

Recent physiological and cognitive studies of schizophrenia have implicated dysfunction of prefrontal cortex as a possible explanation for some of the disabling intellectual and social aspects of the disorder. To investigate the potential reversibility of cognitive deficits and the role of state variables, eg, attention and motivation, three groups of patients with schizophrenia were administered the Wisconsin Card Sorting Test on six consecutive occasions. Two of the groups received incremental information on how to do the test, including explicit card-by-card instruction. The third group served as a control. Regardless of the degree of instruction, patients who could not do the test could not learn it. The deficit did not appear generalized, as patients were able to learn word lists on the Selective Reminding memory test and were not globally demented on the Mini—Mental State Examination. These data suggest that prefrontal-type cognitive deficits in schizophrenia may be more profound than is generally appreciated.

Original languageEnglish (US)
Pages (from-to)1008-1014
Number of pages7
JournalArchives of general psychiatry
Volume44
Issue number11
DOIs
StatePublished - Nov 1987
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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