Further EEG observations in children with the Rett syndrome

E. Niedermeyer, Sakkubai Naidu

Research output: Contribution to journalArticle

Abstract

In four cases of the Rett syndrome (RS) (age 3 1/2 , 6, 11 and 12 years), paroxysmal activity and especially spike discharges over the central region could be blocked or attenuated by passive finger movements. This response, however, is not demonstrable in the majority of children with RS. The blocking or attenuating effect of passive movements is compared with earlier observations of central spike discharges occurring in children with benign Rolandic epilepsy. In some of these children, central spikes could be blocked by active hand movements. It was assumed that such a positive blocking response underscores the 'functional' ('dysfunctional') character of the Rolandic spikes and the lack of local structural damage. In children with cerebral palsy, seizures and central spike (and evidence of structural brain damage), such a blocking response was not obtainable. Taking into consideration these earlier observations, there is reason to presume that the central spike activity found in RS is based on dysfunction rather than on structural impairment.

Original languageEnglish (US)
Pages (from-to)53-54
Number of pages2
JournalBrain and Development
Volume12
Issue number1
StatePublished - 1990

Fingerprint

Rett Syndrome
Electroencephalography
Rolandic Epilepsy
Cerebral Palsy
Fingers
Seizures
Hand
Brain

Keywords

  • benign Rolandic epilepsy
  • blocking effect
  • EEG
  • Rett syndrome
  • Rolandic region
  • spike activity

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Further EEG observations in children with the Rett syndrome. / Niedermeyer, E.; Naidu, Sakkubai.

In: Brain and Development, Vol. 12, No. 1, 1990, p. 53-54.

Research output: Contribution to journalArticle

@article{3866a1ad2840450c8ef10fa10f6f6244,
title = "Further EEG observations in children with the Rett syndrome",
abstract = "In four cases of the Rett syndrome (RS) (age 3 1/2 , 6, 11 and 12 years), paroxysmal activity and especially spike discharges over the central region could be blocked or attenuated by passive finger movements. This response, however, is not demonstrable in the majority of children with RS. The blocking or attenuating effect of passive movements is compared with earlier observations of central spike discharges occurring in children with benign Rolandic epilepsy. In some of these children, central spikes could be blocked by active hand movements. It was assumed that such a positive blocking response underscores the 'functional' ('dysfunctional') character of the Rolandic spikes and the lack of local structural damage. In children with cerebral palsy, seizures and central spike (and evidence of structural brain damage), such a blocking response was not obtainable. Taking into consideration these earlier observations, there is reason to presume that the central spike activity found in RS is based on dysfunction rather than on structural impairment.",
keywords = "benign Rolandic epilepsy, blocking effect, EEG, Rett syndrome, Rolandic region, spike activity",
author = "E. Niedermeyer and Sakkubai Naidu",
year = "1990",
language = "English (US)",
volume = "12",
pages = "53--54",
journal = "Brain and Development",
issn = "0387-7604",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Further EEG observations in children with the Rett syndrome

AU - Niedermeyer, E.

AU - Naidu, Sakkubai

PY - 1990

Y1 - 1990

N2 - In four cases of the Rett syndrome (RS) (age 3 1/2 , 6, 11 and 12 years), paroxysmal activity and especially spike discharges over the central region could be blocked or attenuated by passive finger movements. This response, however, is not demonstrable in the majority of children with RS. The blocking or attenuating effect of passive movements is compared with earlier observations of central spike discharges occurring in children with benign Rolandic epilepsy. In some of these children, central spikes could be blocked by active hand movements. It was assumed that such a positive blocking response underscores the 'functional' ('dysfunctional') character of the Rolandic spikes and the lack of local structural damage. In children with cerebral palsy, seizures and central spike (and evidence of structural brain damage), such a blocking response was not obtainable. Taking into consideration these earlier observations, there is reason to presume that the central spike activity found in RS is based on dysfunction rather than on structural impairment.

AB - In four cases of the Rett syndrome (RS) (age 3 1/2 , 6, 11 and 12 years), paroxysmal activity and especially spike discharges over the central region could be blocked or attenuated by passive finger movements. This response, however, is not demonstrable in the majority of children with RS. The blocking or attenuating effect of passive movements is compared with earlier observations of central spike discharges occurring in children with benign Rolandic epilepsy. In some of these children, central spikes could be blocked by active hand movements. It was assumed that such a positive blocking response underscores the 'functional' ('dysfunctional') character of the Rolandic spikes and the lack of local structural damage. In children with cerebral palsy, seizures and central spike (and evidence of structural brain damage), such a blocking response was not obtainable. Taking into consideration these earlier observations, there is reason to presume that the central spike activity found in RS is based on dysfunction rather than on structural impairment.

KW - benign Rolandic epilepsy

KW - blocking effect

KW - EEG

KW - Rett syndrome

KW - Rolandic region

KW - spike activity

UR - http://www.scopus.com/inward/record.url?scp=0025274471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025274471&partnerID=8YFLogxK

M3 - Article

C2 - 2344027

AN - SCOPUS:0025274471

VL - 12

SP - 53

EP - 54

JO - Brain and Development

JF - Brain and Development

SN - 0387-7604

IS - 1

ER -