Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Anthony Pinto; Benjamin D. Greenberg; Marco A. Grados; O. Joseph Bienvenu; Jack F. Samuels; Dennis L. Murphy; Gregor Hasler; Robert L. Stout; Scott L. Rauch; Yin Y. Shugart; David L. Pauls; James A. Knowles; Abby J. Fyer; James T. McCracken; John Piacentini; Ying Wang; Virginia L. Willour; Bernadette Cullen; Kung Yee Liang; Rudolf Hoehn-Saric; Mark A. Riddle; Steven A. Rasmussen; Gerald Nestadt

doi:10.1016/j.psychres.2007.07.010

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Anthony Pinto, Benjamin D. Greenberg, Marco A. Grados, O. Joseph Bienvenu, Jack F. Samuels, Dennis L. Murphy, Gregor Hasler, Robert L. Stout, Scott L. Rauch, Yin Y. Shugart, David L. Pauls, James A. Knowles, Abby J. Fyer, James T. McCracken, John Piacentini, Ying Wang, Virginia L. Willour, Bernadette Cullen, Kung Yee Liang, Rudolf Hoehn-SaricMark A. Riddle, Steven A. Rasmussen, Gerald Nestadt

School of Medicine

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Despite progress in identifying homogeneous subphenotypes of obsessive-compulsive disorder (OCD) through factor analysis of the Yale Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been few attempts to evaluate the familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item- and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for four of the five factors, Hoarding and Taboo Thoughts were the most robustly familial (r_ICC ≥ 0.2). This report presents considerable converging evidence for a five-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance. The results support investigation of this multidimensional model in OCD genetic linkage studies.

Original language	English (US)
Pages (from-to)	83-93
Number of pages	11
Journal	Psychiatry research
Volume	160
Issue number	1
DOIs	https://doi.org/10.1016/j.psychres.2007.07.010
State	Published - Jul 15 2008

Keywords

Factors
Familial
Genetics
Obsessive compulsive disorder
Symptoms

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2007.07.010

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Pinto, A., Greenberg, B. D., Grados, M. A., Bienvenu, O. J., Samuels, J. F., Murphy, D. L., Hasler, G., Stout, R. L., Rauch, S. L., Shugart, Y. Y., Pauls, D. L., Knowles, J. A., Fyer, A. J., McCracken, J. T., Piacentini, J., Wang, Y., Willour, V. L., Cullen, B., Liang, K. Y., ... Nestadt, G. (2008). Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories. Psychiatry research, 160(1), 83-93. https://doi.org/10.1016/j.psychres.2007.07.010

Pinto, A, Greenberg, BD, Grados, MA , Bienvenu, OJ, Samuels, JF, Murphy, DL, Hasler, G, Stout, RL, Rauch, SL, Shugart, YY, Pauls, DL, Knowles, JA, Fyer, AJ, McCracken, JT, Piacentini, J, Wang, Y, Willour, VL, Cullen, B, Liang, KY, Hoehn-Saric, R, Riddle, MA, Rasmussen, SA & Nestadt, G 2008, 'Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories', Psychiatry research, vol. 160, no. 1, pp. 83-93. https://doi.org/10.1016/j.psychres.2007.07.010

@article{fdd81f884ba24fe38b27e2d2f1a60609,

title = "Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories",

abstract = "Despite progress in identifying homogeneous subphenotypes of obsessive-compulsive disorder (OCD) through factor analysis of the Yale Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been few attempts to evaluate the familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item- and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for four of the five factors, Hoarding and Taboo Thoughts were the most robustly familial (rICC ≥ 0.2). This report presents considerable converging evidence for a five-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance. The results support investigation of this multidimensional model in OCD genetic linkage studies.",

keywords = "Factors, Familial, Genetics, Obsessive compulsive disorder, Symptoms",

author = "Anthony Pinto and Greenberg, {Benjamin D.} and Grados, {Marco A.} and Bienvenu, {O. Joseph} and Samuels, {Jack F.} and Murphy, {Dennis L.} and Gregor Hasler and Stout, {Robert L.} and Rauch, {Scott L.} and Shugart, {Yin Y.} and Pauls, {David L.} and Knowles, {James A.} and Fyer, {Abby J.} and McCracken, {James T.} and John Piacentini and Ying Wang and Willour, {Virginia L.} and Bernadette Cullen and Liang, {Kung Yee} and Rudolf Hoehn-Saric and Riddle, {Mark A.} and Rasmussen, {Steven A.} and Gerald Nestadt",

note = "Funding Information: This research was supported by NIMH grants R01 MH50214, K23 MH064543, and K23 MH066284. The authors are grateful to Karen Bandeen-Roche, PhD, and Paul T. Costa, Jr., PhD, for their input on factor-analytic methods. The authors also thank the many families participating in the study; the Obsessive-Compulsive Foundation; and clinicians and coordinators at each site: Butler Hospital/Brown University (Maria Mancebo, PhD, Richard Marsland, RN, Shirley Yen, PhD); Columbia University (Renee Goodwin, PhD, Joshua Lipsitz, PhD, Jessica Page, PsyD); Johns Hopkins University School of Medicine (Laura Eisen, BS; Karan Lamb, PsyD, Tracey Lichner, PhD, Yung-mei Leong, PhD; Krista Vermillion, BA); Massachusetts General Hospital/Harvard Medical School (Daniel Geller, MD, Anne Chosak, PhD, Michelle Wedig, BS, Evelyn Stewart, MD, Michael Jenike, MD, Beth Gershuny, PhD, Sabine Wilhelm, PhD); NIMH (Lucy Justement, Diane Kazuba, V. Holland LaSalle-Ricci, Theresa B. DeGuzman); University of California—Los Angeles (R. Lindsey Bergman, PhD, Susanna Chang, PhD, Audra Langley, PhD, Amanda Pearlman, BA).",

year = "2008",

month = jul,

day = "15",

doi = "10.1016/j.psychres.2007.07.010",

language = "English (US)",

volume = "160",

pages = "83--93",

journal = "Psychiatry research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - Further development of YBOCS dimensions in the OCD Collaborative Genetics Study

T2 - Symptoms vs. categories

AU - Pinto, Anthony

AU - Greenberg, Benjamin D.

AU - Grados, Marco A.

AU - Bienvenu, O. Joseph

AU - Samuels, Jack F.

AU - Murphy, Dennis L.

AU - Hasler, Gregor

AU - Stout, Robert L.

AU - Rauch, Scott L.

AU - Shugart, Yin Y.

AU - Pauls, David L.

AU - Knowles, James A.

AU - Fyer, Abby J.

AU - McCracken, James T.

AU - Piacentini, John

AU - Wang, Ying

AU - Willour, Virginia L.

AU - Cullen, Bernadette

AU - Liang, Kung Yee

AU - Hoehn-Saric, Rudolf

AU - Riddle, Mark A.

AU - Rasmussen, Steven A.

AU - Nestadt, Gerald

N1 - Funding Information: This research was supported by NIMH grants R01 MH50214, K23 MH064543, and K23 MH066284. The authors are grateful to Karen Bandeen-Roche, PhD, and Paul T. Costa, Jr., PhD, for their input on factor-analytic methods. The authors also thank the many families participating in the study; the Obsessive-Compulsive Foundation; and clinicians and coordinators at each site: Butler Hospital/Brown University (Maria Mancebo, PhD, Richard Marsland, RN, Shirley Yen, PhD); Columbia University (Renee Goodwin, PhD, Joshua Lipsitz, PhD, Jessica Page, PsyD); Johns Hopkins University School of Medicine (Laura Eisen, BS; Karan Lamb, PsyD, Tracey Lichner, PhD, Yung-mei Leong, PhD; Krista Vermillion, BA); Massachusetts General Hospital/Harvard Medical School (Daniel Geller, MD, Anne Chosak, PhD, Michelle Wedig, BS, Evelyn Stewart, MD, Michael Jenike, MD, Beth Gershuny, PhD, Sabine Wilhelm, PhD); NIMH (Lucy Justement, Diane Kazuba, V. Holland LaSalle-Ricci, Theresa B. DeGuzman); University of California—Los Angeles (R. Lindsey Bergman, PhD, Susanna Chang, PhD, Audra Langley, PhD, Amanda Pearlman, BA).

PY - 2008/7/15

Y1 - 2008/7/15

N2 - Despite progress in identifying homogeneous subphenotypes of obsessive-compulsive disorder (OCD) through factor analysis of the Yale Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been few attempts to evaluate the familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item- and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for four of the five factors, Hoarding and Taboo Thoughts were the most robustly familial (rICC ≥ 0.2). This report presents considerable converging evidence for a five-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance. The results support investigation of this multidimensional model in OCD genetic linkage studies.

AB - Despite progress in identifying homogeneous subphenotypes of obsessive-compulsive disorder (OCD) through factor analysis of the Yale Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been few attempts to evaluate the familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item- and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for four of the five factors, Hoarding and Taboo Thoughts were the most robustly familial (rICC ≥ 0.2). This report presents considerable converging evidence for a five-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance. The results support investigation of this multidimensional model in OCD genetic linkage studies.

KW - Factors

KW - Familial

KW - Genetics

KW - Obsessive compulsive disorder

KW - Symptoms

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Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Abstract

Keywords

ASJC Scopus subject areas

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