Further consideration of the clonal nature of Salmonella typhi: Evaluation of molecular and clinical characteristics of strains from Indonesia and Peru

A. Franco, C. Gonzalez, O. S. Levine, R. Lagos, R. H. Hall, S. L. Hoffman, M. A. Moechtar, E. Gotuzzo, M. M. Levine, D. M. Hone, J. G. Morris

Research output: Contribution to journalArticle

Abstract

We examined envelope protein profiles, chromosomal restriction endonuclease digest patterns, and immune responses to envelope proteins for collections of Salmonella typhi strains isolated in Peru and Indonesia. Only minor differences in envelope protein patterns were apparent among strains. Strains from 7 of 20 Indonesian patients had a distinct chromosomal digest pattern compared with patterns of Peruvian and other Indonesian strains. Strains with this pattern carried the gene for the j flagellar antigen (H1- j); differences in response to envelope proteins of j and d strains were noted on immunoblot analysis. Our data suggest that there are genotypic and phenotypic differences among S. typhi strains. The clinical importance of these differences remains to be fully evaluated; however, in this study it was not possible to show a clear correlation between strain characteristics and disease severity.

Original languageEnglish (US)
Pages (from-to)2187-2190
Number of pages4
JournalJournal of Clinical Microbiology
Volume30
Issue number8
StatePublished - 1992
Externally publishedYes

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Salmonella typhi
Peru
Indonesia
Proteins
DNA Restriction Enzymes
Antigens
Genes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Franco, A., Gonzalez, C., Levine, O. S., Lagos, R., Hall, R. H., Hoffman, S. L., ... Morris, J. G. (1992). Further consideration of the clonal nature of Salmonella typhi: Evaluation of molecular and clinical characteristics of strains from Indonesia and Peru. Journal of Clinical Microbiology, 30(8), 2187-2190.

Further consideration of the clonal nature of Salmonella typhi : Evaluation of molecular and clinical characteristics of strains from Indonesia and Peru. / Franco, A.; Gonzalez, C.; Levine, O. S.; Lagos, R.; Hall, R. H.; Hoffman, S. L.; Moechtar, M. A.; Gotuzzo, E.; Levine, M. M.; Hone, D. M.; Morris, J. G.

In: Journal of Clinical Microbiology, Vol. 30, No. 8, 1992, p. 2187-2190.

Research output: Contribution to journalArticle

Franco, A, Gonzalez, C, Levine, OS, Lagos, R, Hall, RH, Hoffman, SL, Moechtar, MA, Gotuzzo, E, Levine, MM, Hone, DM & Morris, JG 1992, 'Further consideration of the clonal nature of Salmonella typhi: Evaluation of molecular and clinical characteristics of strains from Indonesia and Peru', Journal of Clinical Microbiology, vol. 30, no. 8, pp. 2187-2190.
Franco, A. ; Gonzalez, C. ; Levine, O. S. ; Lagos, R. ; Hall, R. H. ; Hoffman, S. L. ; Moechtar, M. A. ; Gotuzzo, E. ; Levine, M. M. ; Hone, D. M. ; Morris, J. G. / Further consideration of the clonal nature of Salmonella typhi : Evaluation of molecular and clinical characteristics of strains from Indonesia and Peru. In: Journal of Clinical Microbiology. 1992 ; Vol. 30, No. 8. pp. 2187-2190.
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AU - Lagos, R.

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AU - Hoffman, S. L.

AU - Moechtar, M. A.

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