Fungicidal effect of resveratrol on human infectious fungi

Jun Jung Hyun; Ah Hwang In; Sang Sung Woo; Hyungu Kang; Sik Kang Beom; Bae Seu Young; Gun Lee Dong

doi:10.1007/bf02977758

Fungicidal effect of resveratrol on human infectious fungi

Jun Jung Hyun, Ah Hwang In, Sang Sung Woo, Hyungu Kang, Sik Kang Beom, Bae Seu Young, Gun Lee Dong

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 μg/mL. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.

Original language	English (US)
Pages (from-to)	557-560
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	28
Issue number	5
DOIs	https://doi.org/10.1007/bf02977758
State	Published - May 31 2005
Externally published	Yes

Keywords

Fungicidal activity
Hemolytic effect
Phenolic antioxidant
Resveratrol
trans-3,5,4′-trihydroxystilbene

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/bf02977758

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title = "Fungicidal effect of resveratrol on human infectious fungi",

abstract = "Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 μg/mL. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.",

keywords = "Fungicidal activity, Hemolytic effect, Phenolic antioxidant, Resveratrol, trans-3,5,4′-trihydroxystilbene",

author = "Hyun, {Jun Jung} and In, {Ah Hwang} and Woo, {Sang Sung} and Hyungu Kang and Beom, {Sik Kang} and Young, {Bae Seu} and Dong, {Gun Lee}",

note = "Funding Information: This research was supported by Kyungpook National University Research Fund, 2003.",

year = "2005",

month = may,

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doi = "10.1007/bf02977758",

language = "English (US)",

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T1 - Fungicidal effect of resveratrol on human infectious fungi

AU - Hyun, Jun Jung

AU - In, Ah Hwang

AU - Woo, Sang Sung

AU - Kang, Hyungu

AU - Beom, Sik Kang

AU - Young, Bae Seu

AU - Dong, Gun Lee

N1 - Funding Information: This research was supported by Kyungpook National University Research Fund, 2003.

PY - 2005/5/31

Y1 - 2005/5/31

N2 - Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 μg/mL. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.

AB - Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 μg/mL. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.

KW - Fungicidal activity

KW - Hemolytic effect

KW - Phenolic antioxidant

KW - Resveratrol

KW - trans-3,5,4′-trihydroxystilbene

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EP - 560

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 5

ER -

Fungicidal effect of resveratrol on human infectious fungi

Abstract

Keywords

ASJC Scopus subject areas

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