Fungicidal and binding properties of the natural peptides cecropin B and dermaseptin

A. J. De Lucca, J. M. Bland, T. J. Jacks, C. Grimm, T. J. Walsh

Research output: Contribution to journalArticlepeer-review


In vitro fungicidal properties of cecropin B and dermaseptin were explored using nongerminating and germinating conidia from Aspergillus flavus, A. fumigatus, A. niger, Fusarium moniliforme and F. oxysporum. Cecropin B produced LD50 values for germinating A. flavus, A. fumigatus and A. niger conidia of 3-0, 0-5 and 2-0 UM, respectively, while dermaseptin gave LD50 values of 4-0, 0-05 and 2-0 JUM, respectively. Cecropin B produced an LD50 value of 0-2 /IM for non-germinating F. moniliforme and F. oxysporum conidia, while dermaseptin did not reduce either as much as 50% at any level tested. LD50 levels for CB were 0-2 and 0-1 fiM, respectively, for germinating F. moniliforme and F. oxysporum conidia. Dermaseptin was less effective, giving LD50 values for germinating F. moniliforme and F. oxysporum conidia of 0-3 and 0-8 UM, respectively. Neither peptide reduced conidial viabilities of non-germinating Aspergillus spp. Physicochemical studies indicated cecropin B and dermaseptin bound to ergosterol and cholesterol, conidial wall constituents, but not to chitin or /M,3-glucan.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalJournal of Medical and Veterinary Mycology
Issue number5
StatePublished - 1998
Externally publishedYes


  • Cecropin b
  • Conidia
  • Dermaseptin
  • Fungicidal
  • Peptides

ASJC Scopus subject areas

  • Microbiology


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