Fungal lethality, binding, and cytotoxicity of syringomycin-E

A. J. De Lucca, T. J. Jacks, J. Takemoto, B. Vinyard, J. Peter, E. Navarro, T. J. Walsh

Research output: Contribution to journalArticle

Abstract

Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 μg/ml. SE complexed with the following fungal wall constituents (in order of binding): β-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.

Original languageEnglish (US)
Pages (from-to)371-373
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number2
StatePublished - Feb 1999
Externally publishedYes

Fingerprint

Mannans
Ergosterol
Chitin
Glucans
Fusarium
Aspergillus
HeLa Cells
Fungi
Cholesterol
syringomycin E

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

De Lucca, A. J., Jacks, T. J., Takemoto, J., Vinyard, B., Peter, J., Navarro, E., & Walsh, T. J. (1999). Fungal lethality, binding, and cytotoxicity of syringomycin-E. Antimicrobial Agents and Chemotherapy, 43(2), 371-373.

Fungal lethality, binding, and cytotoxicity of syringomycin-E. / De Lucca, A. J.; Jacks, T. J.; Takemoto, J.; Vinyard, B.; Peter, J.; Navarro, E.; Walsh, T. J.

In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 2, 02.1999, p. 371-373.

Research output: Contribution to journalArticle

De Lucca, AJ, Jacks, TJ, Takemoto, J, Vinyard, B, Peter, J, Navarro, E & Walsh, TJ 1999, 'Fungal lethality, binding, and cytotoxicity of syringomycin-E', Antimicrobial Agents and Chemotherapy, vol. 43, no. 2, pp. 371-373.
De Lucca AJ, Jacks TJ, Takemoto J, Vinyard B, Peter J, Navarro E et al. Fungal lethality, binding, and cytotoxicity of syringomycin-E. Antimicrobial Agents and Chemotherapy. 1999 Feb;43(2):371-373.
De Lucca, A. J. ; Jacks, T. J. ; Takemoto, J. ; Vinyard, B. ; Peter, J. ; Navarro, E. ; Walsh, T. J. / Fungal lethality, binding, and cytotoxicity of syringomycin-E. In: Antimicrobial Agents and Chemotherapy. 1999 ; Vol. 43, No. 2. pp. 371-373.
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