Fungal lethality, binding, and cytotoxicity of syringomycin-E

A. J. De Lucca, T. J. Jacks, J. Takemoto, B. Vinyard, J. Peter, E. Navarro, T. J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 μg/ml. SE complexed with the following fungal wall constituents (in order of binding): β-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.

Original languageEnglish (US)
Pages (from-to)371-373
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume43
Issue number2
DOIs
StatePublished - Feb 1999

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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