Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 μg/ml. SE complexed with the following fungal wall constituents (in order of binding): β-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.
|Original language||English (US)|
|Number of pages||3|
|Journal||Antimicrobial agents and chemotherapy|
|State||Published - Feb 1 1999|
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases