Fungal infections in patients undergoing blood and marrow transplantation

K. A. Marr, R. A. Bowden

Research output: Contribution to journalArticlepeer-review

Abstract

Fungal infections are currently a leading cause of infectious morbidity and mortality in patients undergoing allogeneic blood and marrow transplantation (BMT). Although the introduction of azole antifungals for prophylaxis has had a significant impact on the incidence of candidal infections (especially those caused by C albicans and C tropicalis), invasive aspergillosis has increased in incidence in many centers worldwide. Given the long risk period corresponding with graft-versus-host disease, and the toxicities of currently available mold-active antifungals, the development of a prevention strategy for these angioinvasive molds remains a challenge. The introduction of new antifungal drugs and adjunctive therapy to improve immune function may be beneficial in decreasing mortality associated with these infections in the future. Most importantly, a greater understanding of the pathogenesis of fungal disease and specific host risks is necessary to impact this increasingly important infection in immunocompromised hosts.

Original languageEnglish (US)
Pages (from-to)237-246
Number of pages10
JournalTransplant Infectious Disease
Volume1
Issue number4
DOIs
StatePublished - Dec 1999
Externally publishedYes

Keywords

  • Blood and marrow transplant infections
  • Fungal infection
  • Mycoses

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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