Fungal infection presenting as giant cell tubulointerstitial nephritis in kidney allograft

S. M. Bagnasco, A. K. Subramanian, N. M. Desai

Research output: Contribution to journalArticlepeer-review

Abstract

Giant cell tubulointerstitial nephritis in the kidney allograft caused by infection is rare, and donor-transmitted infection in transplanted kidneys is also rare. In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53-year-old male kidney transplant recipient with decreased renal function 12 days post transplant. Several giant cells were present in the tubulointerstitial inflammation, as well as yeasts, with no evidence of rejection, and the histological diagnosis was confirmed by urine culture. Donor urine culture was positive for C. albicans, suggestive of a possible donor-transmitted infection. Prompt antifungal treatment eradicated the infection, and averted systemic spread. To our knowledge, there are no previous reports of Candida infection with giant cell tubulointerstitial nephritis in human renal allograft.

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalTransplant Infectious Disease
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2012

Keywords

  • Biopsy
  • Candida
  • Donor-transmitted
  • Giant cell
  • Kidney transplant

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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