TY - JOUR
T1 - Fungal extracellular vesicles as potential targets for immune interventions
AU - Freitas, Mateus Silveira
AU - Bonato, Vânia Luiza Deperon
AU - Pessoni, Andre Moreira a.
AU - Rodrigues, Marcio L.
AU - Casadevall, Arturo
AU - Almeida, Fausto
N1 - Funding Information:
We acknowledge support from the Fundação de Amparo a Pesquisa do Estado de São Paulo (grant 2016/03322-7), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and the Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças de Populações Negligenciadas (INCT-IDPN).
Funding Information:
We acknowledge support from the Funda??o de Amparo a Pesquisa do Estado de S?o Paulo (grant 2016/03322-7), the Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq), the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES), and the Instituto Nacional de Ci?ncia e Tecnologia de Inova??o em Doen?as de Popula??es Negligenciadas (INCT-IDPN).
Publisher Copyright:
© 2019 Freitas et al.
PY - 2019
Y1 - 2019
N2 - The release of extracellular vesicles (EVs) by fungi is a fundamental cellular process. EVs carry several biomolecules, including pigments, proteins, enzymes, lipids, nucleic acids, and carbohydrates, and are involved in physiological and pathological processes. EVs may play a pivotal role in the establishment of fungal infections, as they can interact with the host immune system to elicit multiple outcomes. It has been observed that, depending on the fungal pathogen, EVs can exacerbate or attenuate fungal infections. The study of the interaction between fungal EVs and the host immune system and understanding of the mechanisms that regulate those interactions might be useful for the development of new adjuvants as well as the improvement of protective immune responses against infectious or noninfectious diseases. In this review, we describe the immunomodulatory properties of EVs produced by pathogenic fungi and discuss their potential as adjuvants for prophylactic or therapeutic strategies.
AB - The release of extracellular vesicles (EVs) by fungi is a fundamental cellular process. EVs carry several biomolecules, including pigments, proteins, enzymes, lipids, nucleic acids, and carbohydrates, and are involved in physiological and pathological processes. EVs may play a pivotal role in the establishment of fungal infections, as they can interact with the host immune system to elicit multiple outcomes. It has been observed that, depending on the fungal pathogen, EVs can exacerbate or attenuate fungal infections. The study of the interaction between fungal EVs and the host immune system and understanding of the mechanisms that regulate those interactions might be useful for the development of new adjuvants as well as the improvement of protective immune responses against infectious or noninfectious diseases. In this review, we describe the immunomodulatory properties of EVs produced by pathogenic fungi and discuss their potential as adjuvants for prophylactic or therapeutic strategies.
KW - Drug targets
KW - Extracellular vesicles
KW - Fungal infections
KW - Immune response
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U2 - 10.1128/mSphere.00747-19
DO - 10.1128/mSphere.00747-19
M3 - Short survey
C2 - 31694899
AN - SCOPUS:85074624400
SN - 2379-5042
VL - 4
JO - mSphere
JF - mSphere
IS - 6
M1 - e00747
ER -