Fundus Flavimaculatus without Maculopathy: A Clinicopathologic Study

Peter J. McDonnell, Jane D. Kivlin, Irene H. Maumenee, W. Richard Green

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the eyes of a 51-year-old man with the clinical diagnosis of fundus Flavimaculatus without macular involvement by light and electron microscopy. Scanning and transmission electron microscopy revealed elevated aggregates of enlarged retinal pigment epithelial cells with apices distended by accumulated lipid membranes with a tubulo-vesicular appearance. Histochemical and ultrastructural studies failed to demonstrate abnormal accumulation of lipofuscin or acid mucopolysaccharide. The disorder, known clinically as fundus flavimaculatus, may represent two or more metabolic disorders of the retinal pigment epithelium characterized by distinct histochemical and ultrastructural features.

Original languageEnglish (US)
Pages (from-to)116-119
Number of pages4
JournalOphthalmology
Volume93
Issue number1
DOIs
StatePublished - Jan 1 1986

Keywords

  • Stargardt's disease
  • fundus flavimaculatus
  • histopathology
  • lipofuscin
  • melanolipofuscin
  • retinal pigment epithelium
  • scanning electron microscopy
  • transmission electron microscopy

ASJC Scopus subject areas

  • Ophthalmology

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