Fundus autofluorescence patterns in primary intraocular lymphoma

Megan Casady, Lisa Faia, Maryam Nazemzadeh, Robert Nussenblatt, Chi Chao Chan, H. Nida Sen

Research output: Contribution to journalArticle

Abstract

PURPOSE: To evaluate fundus autofluorescence (FAF) patterns in patients with primary intraocular (vitreoretinal) lymphoma. METHODS: Records of all patients with primary intraocular lymphoma who underwent FAF imaging at the National Eye Institute were reviewed. Fundus autofluorescence patterns were evaluated with respect to clinical disease status and the findings on fluorescein angiography and spectral-domain optical coherence tomography. RESULTS: There were 18 eyes (10 patients) with primary intraocular lymphoma that underwent FAF imaging. Abnormal autofluorescence in the form of granular hyperautofluorescence and hypoautofluorescence was seen in 11 eyes (61%), and blockage by mass lesion was seen in 2 eyes (11%). All eyes with granular pattern on FAF had active primary intraocular lymphoma at the time of imaging, but there were 5 eyes with unremarkable FAF, which were found to have active lymphoma. The most common pattern on fluorescein angiography was hypofluorescent round spots with a "leopard spot" appearance (43%). These hypofluorescent spots on fluorescein angiography correlated with hyperautofluorescent spots on FAF in 5 eyes (36%) (inversion of FAF). Nodular hyperreflective spots at the level of retinal pigment epithelium on optical coherence tomography were noted in 43% of eyes. The hyperautofluorescent spots on FAF correlated with nodular hyperreflective spots on optical coherence tomography in 6 eyes (43%). CONCLUSION: Granularity on FAF was associated with active lymphoma in majority of the cases. An inversion of FAF (hyperautofluorescent spots on FAF corresponding to hypofluorescent spots on fluorescein angiography) was observed in less than half of the eyes.

Original languageEnglish (US)
Pages (from-to)366-372
Number of pages7
JournalRetina
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Fingerprint

Intraocular Lymphoma
Fluorescein Angiography
Optical Coherence Tomography
Optical Imaging
Lymphoma
National Eye Institute (U.S.)
Panthera
Retinal Pigment Epithelium

Keywords

  • Cytokines
  • Diagnosis
  • Fundus autofluorescence
  • Primary intraocular lymphoma
  • Primary vitreoretinal lymphoma
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Casady, M., Faia, L., Nazemzadeh, M., Nussenblatt, R., Chan, C. C., & Sen, H. N. (2014). Fundus autofluorescence patterns in primary intraocular lymphoma. Retina, 34(2), 366-372. https://doi.org/10.1097/IAE.0b013e31829977fa

Fundus autofluorescence patterns in primary intraocular lymphoma. / Casady, Megan; Faia, Lisa; Nazemzadeh, Maryam; Nussenblatt, Robert; Chan, Chi Chao; Sen, H. Nida.

In: Retina, Vol. 34, No. 2, 01.02.2014, p. 366-372.

Research output: Contribution to journalArticle

Casady, M, Faia, L, Nazemzadeh, M, Nussenblatt, R, Chan, CC & Sen, HN 2014, 'Fundus autofluorescence patterns in primary intraocular lymphoma', Retina, vol. 34, no. 2, pp. 366-372. https://doi.org/10.1097/IAE.0b013e31829977fa
Casady M, Faia L, Nazemzadeh M, Nussenblatt R, Chan CC, Sen HN. Fundus autofluorescence patterns in primary intraocular lymphoma. Retina. 2014 Feb 1;34(2):366-372. https://doi.org/10.1097/IAE.0b013e31829977fa
Casady, Megan ; Faia, Lisa ; Nazemzadeh, Maryam ; Nussenblatt, Robert ; Chan, Chi Chao ; Sen, H. Nida. / Fundus autofluorescence patterns in primary intraocular lymphoma. In: Retina. 2014 ; Vol. 34, No. 2. pp. 366-372.
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AB - PURPOSE: To evaluate fundus autofluorescence (FAF) patterns in patients with primary intraocular (vitreoretinal) lymphoma. METHODS: Records of all patients with primary intraocular lymphoma who underwent FAF imaging at the National Eye Institute were reviewed. Fundus autofluorescence patterns were evaluated with respect to clinical disease status and the findings on fluorescein angiography and spectral-domain optical coherence tomography. RESULTS: There were 18 eyes (10 patients) with primary intraocular lymphoma that underwent FAF imaging. Abnormal autofluorescence in the form of granular hyperautofluorescence and hypoautofluorescence was seen in 11 eyes (61%), and blockage by mass lesion was seen in 2 eyes (11%). All eyes with granular pattern on FAF had active primary intraocular lymphoma at the time of imaging, but there were 5 eyes with unremarkable FAF, which were found to have active lymphoma. The most common pattern on fluorescein angiography was hypofluorescent round spots with a "leopard spot" appearance (43%). These hypofluorescent spots on fluorescein angiography correlated with hyperautofluorescent spots on FAF in 5 eyes (36%) (inversion of FAF). Nodular hyperreflective spots at the level of retinal pigment epithelium on optical coherence tomography were noted in 43% of eyes. The hyperautofluorescent spots on FAF correlated with nodular hyperreflective spots on optical coherence tomography in 6 eyes (43%). CONCLUSION: Granularity on FAF was associated with active lymphoma in majority of the cases. An inversion of FAF (hyperautofluorescent spots on FAF corresponding to hypofluorescent spots on fluorescein angiography) was observed in less than half of the eyes.

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