TY - JOUR
T1 - Fundus Autofluorescence and Progression of Age-related Macular Degeneration
AU - Schmitz-Valckenberg, Steffen
AU - Fleckenstein, Monika
AU - Scholl, Hendrik P.N.
AU - Holz, Frank G.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Fundus autofluorescence imaging is an imaging method that provides additional information compared to conventional imaging techniques. It permits to topographically map lipofuscin distribution of the retinal pigment epithelial cell monolayer. Excessive accumulation of lipofuscin granules in the lysosomal compartment of retinal pigment epithelium cells represents a common downstream pathogenetic pathway in various hereditary and complex retinal diseases including age-related macular degeneration (AMD). This comprehensive review contains an introduction in fundus autofluorescence imaging, including basic considerations, the origin of the signal, different imaging methods, and a brief overview of fundus autofluorescence findings in normal subjects. Furthermore, it summarizes cross-sectional and longitudinal fundus autofluorescence findings in patients with AMD, addresses the pathophysiological significance of increased fundus autofluorescence, and characterizes different fundus autofluorescence phenotypes as well as fundus autofluorescence alterations with disease progression.
AB - Fundus autofluorescence imaging is an imaging method that provides additional information compared to conventional imaging techniques. It permits to topographically map lipofuscin distribution of the retinal pigment epithelial cell monolayer. Excessive accumulation of lipofuscin granules in the lysosomal compartment of retinal pigment epithelium cells represents a common downstream pathogenetic pathway in various hereditary and complex retinal diseases including age-related macular degeneration (AMD). This comprehensive review contains an introduction in fundus autofluorescence imaging, including basic considerations, the origin of the signal, different imaging methods, and a brief overview of fundus autofluorescence findings in normal subjects. Furthermore, it summarizes cross-sectional and longitudinal fundus autofluorescence findings in patients with AMD, addresses the pathophysiological significance of increased fundus autofluorescence, and characterizes different fundus autofluorescence phenotypes as well as fundus autofluorescence alterations with disease progression.
KW - age-related macular degeneration
KW - fundus autofluorescence
KW - lipofuscin
KW - retinal autofluorescence
KW - retinal pigment epithelium
KW - scanning laser ophthalmoscopy
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U2 - 10.1016/j.survophthal.2008.10.004
DO - 10.1016/j.survophthal.2008.10.004
M3 - Article
C2 - 19171212
AN - SCOPUS:58449086657
SN - 0039-6257
VL - 54
SP - 96
EP - 117
JO - Survey of ophthalmology
JF - Survey of ophthalmology
IS - 1
ER -