Functions of netrins and semaphorins in axon guidance

Joseph G. Culotti, Alex L. Kolodkin

Research output: Contribution to journalArticle


Neuronal growth cones respond to both contact-mediated and chemotropic guidance cues; these cues can be either attractive or repulsive. This past year has seen further characterization of two gene families implicated in long-range chemoattraction and chemorepulsion: the netrins and the semaphorins. Analysis of invertebrate members of these gene families demonstrates in vivo how netrins play multiple roles in axonal guidance in Caenorhabditis elegans, how specific domains of the netrin molecule confer attractive and repulsive guidance cues, and how semaphorins can function to generate neuromuscular specificity.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Neuroscience(all)

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