Abstract
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.
Original language | English (US) |
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Pages (from-to) | 555-559 |
Number of pages | 5 |
Journal | Nature medicine |
Volume | 21 |
Issue number | 6 |
DOIs | |
State | Published - Jun 9 2015 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology