Functionalization of the alicyclic skeleton of epibatidine: Synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues

Zhi Liang Wei, Yingxian Xiao, Clifford George, Kenneth J. Kellar, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

A novel method for the epimerization of endo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptan-3-one (12) on silica gel was developed and used as the key step to synthesize functionalized analogues of epibatidine which were evaluated for their nicotine receptor subtype selectivity in binding studies.

Original languageEnglish (US)
Pages (from-to)3878-3881
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number22
DOIs
StatePublished - Nov 21 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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