Functional relevance of neurotransmitter receptor heteromers in the central nervous system

Sergi Ferré, Francisco Ciruela, Amina S. Woods, Carme Lluis, Rafael Franco

Research output: Contribution to journalArticle

Abstract

The existence of neurotransmitter receptor heteromers is becoming broadly accepted and their functional significance is being revealed. Heteromerization of neurotransmitter receptors produces functional entities that possess different biochemical characteristics with respect to the individual components of the heteromer. Neurotransmitter receptor heteromers can function as processors of computations that modulate cell signaling. Thus, the quantitative or qualitative aspects of the signaling generated by stimulation of any of the individual receptor units in the heteromer are different from those obtained during coactivation. Furthermore, recent studies demonstrate that some neurotransmitter receptor heteromers can exert an effect as processors of computations that directly modulate both pre- and postsynaptic neurotransmission. This is illustrated by the analysis of striatal receptor heteromers that control striatal glutamatergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)440-446
Number of pages7
JournalTrends in Neurosciences
Volume30
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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