Abstract
Little information exists on the functional impact of effective antiemetic protection. In the present study, the Functional Living Index - Emesis (FLIE), was used to assess patient-reported impact of chemotherapy-induced nausea and vomiting (CINV) after administration of a new NK-1 receptor antagonist (aprepitant). Cisplatin-treated patients in a double-blind randomised trial received either aprepitant+dexamethasone+ondansetron on day 1 and aprepitant+dexamethasone on days 2-5 or standard antiemetic therapy (dexamethasone and ondansetron on day 1 and dexamethasone on days 2-5). Emetic events, nausea ratings and rescue medications were recorded in a 5-day diary and the FLIE was completed on day 6. Compared with standard therapy, significantly more patients treated with the high dose aprepitant regimen achieved a Complete Response (71 vs 44%, P<0.001) and also reported no impact on daily life as indicated by the FLIE total score (84 vs 66%, P<0.01). Use of the FLIE demonstrated that improved control of emesis was highly effective in reducing the impact of CINV on patients' daily lives.
Original language | English (US) |
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Pages (from-to) | 1395-1401 |
Number of pages | 7 |
Journal | European Journal of Cancer |
Volume | 39 |
Issue number | 10 |
DOIs | |
State | Published - Jul 2003 |
Externally published | Yes |
Keywords
- Antiemetics
- FLIE
- Nausea
- Patient-reported outcomes
- Quality of life
- Vomiting
ASJC Scopus subject areas
- Oncology
- Cancer Research