Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1

Svetlana Lutsenko, Ruslan Tsivkovskii, Joel M. Walker

Research output: Contribution to journalArticle

Abstract

Wilson's disease protein (WNDP) is a copper-transporting P1-type ATPase which plays a key role in normal distribution of copper in a number of tissues, particularly in the liver and the brain. Copper has numerous effects on WNDP, altering its structure, activity, and intracellular localization. To better understand the function of this copper-transporting ATPase and its regulation by copper, we have recently developed the functional expression systems for WNDP and for Atox1, a cytosolic protein that serves as an intracellular donor of copper for WNDP. Here we summarize the results of our experiments on characterization of the enzymatic properties of WNDP and the effects of Atox1 on the WNDP activity.

Original languageEnglish (US)
Pages (from-to)204-211
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume986
StatePublished - 2003
Externally publishedYes

Fingerprint

Metallochaperones
Copper
Normal Distribution
Normal distribution
Liver
Adenosine Triphosphatases
Wilson disease protein
copper-transporting ATPases
Protein
Brain
Tissue

Keywords

  • Atox1
  • ATP7B
  • Copper
  • Metallochaperone
  • Regulation
  • Wilson's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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AU - Lutsenko, Svetlana

AU - Tsivkovskii, Ruslan

AU - Walker, Joel M.

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