Functional properties of hemoglobins intramolecularly crosslinked with tricarboxylic and dicarboxylic acids

E. Bucci, A. Razynska, H. Kwansa, Clara Fronticelli

Research output: Contribution to journalArticle

Abstract

The paper discusses the functional properties of hemoglobins intramolecularly crosslinked with tricarboxylic and dicarboxylic acids. Intramolecular crosslinks are produced either between the α99 or β82 lysines. The increasing length of the crosslink between the β subunits from 4 to 14 carbon atoms progressively decreases the oxygen affinity of hemoglobin. Preliminary data suggest that the same may be true for the crosslinks between α subunits. The triester of benzene-tricarboxylic acid produces very homogeneous β-β crosslinked hemoglobins, with low oxygen affinity.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994
Externally publishedYes

Fingerprint

Tricarboxylic Acids
Dicarboxylic Acids
Hemoglobin
Hemoglobins
Acids
Oxygen
Benzene
Lysine
Carbon
Atoms

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Functional properties of hemoglobins intramolecularly crosslinked with tricarboxylic and dicarboxylic acids. / Bucci, E.; Razynska, A.; Kwansa, H.; Fronticelli, Clara.

In: Artificial Cells, Blood Substitutes, and Biotechnology, Vol. 22, No. 5, 11.1994.

Research output: Contribution to journalArticle

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