Abstract
While decellularized myocardium provides biological cues that direct cardiomyocytes organization and function, repopulating it to create a highly functional electrical and mechanical syncytium has proved challenging. Blazeski and colleagues have created engineered heart slices from thin decellularized sheets, and heart cells derived from reprogrammed human skin cells, that can be used for long-term electrophysiological and contractile studies and drug testing.
Original language | English (US) |
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Pages (from-to) | 982-995 |
Number of pages | 14 |
Journal | Stem Cell Reports |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - May 14 2019 |
Keywords
- cardiac tissue engineering
- electrophysiology
- extracellular matrix
- induced pluripotent stem cells
- scaffold
ASJC Scopus subject areas
- Biochemistry
- Genetics
- Developmental Biology
- Cell Biology