Functional Properties of Engineered Heart Slices Incorporating Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Adriana Blazeski, Justin Lowenthal, Renjun Zhu, Jourdan Ewoldt, Kenneth R. Boheler, Leslie Tung

Research output: Contribution to journalArticle

Abstract

While decellularized myocardium provides biological cues that direct cardiomyocytes organization and function, repopulating it to create a highly functional electrical and mechanical syncytium has proved challenging. Blazeski and colleagues have created engineered heart slices from thin decellularized sheets, and heart cells derived from reprogrammed human skin cells, that can be used for long-term electrophysiological and contractile studies and drug testing.

Original languageEnglish (US)
Pages (from-to)982-995
Number of pages14
JournalStem Cell Reports
Volume12
Issue number5
DOIs
StatePublished - May 14 2019

Keywords

  • cardiac tissue engineering
  • electrophysiology
  • extracellular matrix
  • induced pluripotent stem cells
  • scaffold

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Functional Properties of Engineered Heart Slices Incorporating Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes'. Together they form a unique fingerprint.

  • Cite this