Observational studies have consistently documented independent, strong associations of anemia-even if not severe-with major adverse functional outcomes in older adults. In this chapter, recent epidemiologic evidence linking mild anemia with decline in physical and cognitive function, frailty, and disability in community-dwelling older adults is reviewed. Altogether, these biologically plausible associations provide empirical, though not conclusive, support for the notion of mild anemia as a cause of adverse functional outcomes in older adults. Randomized clinical trial data assessing the impact of anemia correction on functional outcomes are lacking at this time.
|Original language||English (US)|
|Number of pages||6|
|Journal||Seminars in Hematology|
|State||Published - Oct 1 2008|
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