Functional neuroimaging of genetic variation in serotonergic neurotransmission

A. R. Hariri, Daniel Weinberger

Research output: Contribution to journalReview article

Abstract

Serotonin (5-hydroxytryptamine; 5-HT) is a potent modulator of the physiology and behavior involved in generating appropriate responses to environmental cues such as danger or threat. Furthermore, genetic variation in 5-HT subsystem genes can impact upon several dimensions of emotional behavior including neuroticism and psychopathology, but especially anxiety traits. Recently, functional neuroimaging has provided a dramatic illustration of how a promoter polymorphism in the human 5-HT transporter (5-HTT) gene, which has been weakly related to these behaviors, is strongly related to the engagement of neural systems, namely the amygdala, subserving emotional processes. In this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-HT subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. We argue that in time, such knowledge will allow us to not only transcend phenomenological diagnosis and represent mechanisms of disease, but also identify at-risk individuals and biological pathways for the development of new treatments.

Original languageEnglish (US)
Pages (from-to)341-349
Number of pages9
JournalGenes, Brain and Behavior
Volume2
Issue number6
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Functional Neuroimaging
Synaptic Transmission
Serotonin
Genes
Temperament
Amygdala
Psychopathology
Cues
Anxiety

Keywords

  • Amygdala
  • Emotion
  • FMRI
  • PET
  • Prefrontal cortex
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Genetics

Cite this

Functional neuroimaging of genetic variation in serotonergic neurotransmission. / Hariri, A. R.; Weinberger, Daniel.

In: Genes, Brain and Behavior, Vol. 2, No. 6, 2003, p. 341-349.

Research output: Contribution to journalReview article

@article{638ac9a0ba8f4cf199204bc793adeba9,
title = "Functional neuroimaging of genetic variation in serotonergic neurotransmission",
abstract = "Serotonin (5-hydroxytryptamine; 5-HT) is a potent modulator of the physiology and behavior involved in generating appropriate responses to environmental cues such as danger or threat. Furthermore, genetic variation in 5-HT subsystem genes can impact upon several dimensions of emotional behavior including neuroticism and psychopathology, but especially anxiety traits. Recently, functional neuroimaging has provided a dramatic illustration of how a promoter polymorphism in the human 5-HT transporter (5-HTT) gene, which has been weakly related to these behaviors, is strongly related to the engagement of neural systems, namely the amygdala, subserving emotional processes. In this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-HT subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. We argue that in time, such knowledge will allow us to not only transcend phenomenological diagnosis and represent mechanisms of disease, but also identify at-risk individuals and biological pathways for the development of new treatments.",
keywords = "Amygdala, Emotion, FMRI, PET, Prefrontal cortex, Serotonin",
author = "Hariri, {A. R.} and Daniel Weinberger",
year = "2003",
doi = "10.1046/j.1601-1848.2003.00048.x",
language = "English (US)",
volume = "2",
pages = "341--349",
journal = "Genes, Brain and Behavior",
issn = "1601-1848",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Functional neuroimaging of genetic variation in serotonergic neurotransmission

AU - Hariri, A. R.

AU - Weinberger, Daniel

PY - 2003

Y1 - 2003

N2 - Serotonin (5-hydroxytryptamine; 5-HT) is a potent modulator of the physiology and behavior involved in generating appropriate responses to environmental cues such as danger or threat. Furthermore, genetic variation in 5-HT subsystem genes can impact upon several dimensions of emotional behavior including neuroticism and psychopathology, but especially anxiety traits. Recently, functional neuroimaging has provided a dramatic illustration of how a promoter polymorphism in the human 5-HT transporter (5-HTT) gene, which has been weakly related to these behaviors, is strongly related to the engagement of neural systems, namely the amygdala, subserving emotional processes. In this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-HT subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. We argue that in time, such knowledge will allow us to not only transcend phenomenological diagnosis and represent mechanisms of disease, but also identify at-risk individuals and biological pathways for the development of new treatments.

AB - Serotonin (5-hydroxytryptamine; 5-HT) is a potent modulator of the physiology and behavior involved in generating appropriate responses to environmental cues such as danger or threat. Furthermore, genetic variation in 5-HT subsystem genes can impact upon several dimensions of emotional behavior including neuroticism and psychopathology, but especially anxiety traits. Recently, functional neuroimaging has provided a dramatic illustration of how a promoter polymorphism in the human 5-HT transporter (5-HTT) gene, which has been weakly related to these behaviors, is strongly related to the engagement of neural systems, namely the amygdala, subserving emotional processes. In this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-HT subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. We argue that in time, such knowledge will allow us to not only transcend phenomenological diagnosis and represent mechanisms of disease, but also identify at-risk individuals and biological pathways for the development of new treatments.

KW - Amygdala

KW - Emotion

KW - FMRI

KW - PET

KW - Prefrontal cortex

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0344874714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344874714&partnerID=8YFLogxK

U2 - 10.1046/j.1601-1848.2003.00048.x

DO - 10.1046/j.1601-1848.2003.00048.x

M3 - Review article

C2 - 14653306

AN - SCOPUS:0344874714

VL - 2

SP - 341

EP - 349

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

SN - 1601-1848

IS - 6

ER -