Functional Neuroimaging in Geriatric Depression

Faith M. Gunning, Gwenn S. Smith

Research output: Contribution to journalReview articlepeer-review


Abnormalities in specific cerebral networks likely confer vulnerability that increases the susceptibility for development of geriatric depression and affect the course of symptoms. Functional neuroimaging enables the in vivo identification of alterations in cerebral function that characterize disease vulnerability and contribute to variability in depressive symptoms and antidepressant response. Judicious use of functional neuroimaging tools can advance pathophysiologic models of geriatric depression. Furthermore, geriatric depression provides a logical context within which to study the role of specific functional abnormalities in both antidepressant response and key behavioral and cognitive abnormalities of mood disorders.

Original languageEnglish (US)
Pages (from-to)403-422
Number of pages20
JournalPsychiatric Clinics of North America
Issue number2
StatePublished - Jun 2011


  • FMRI
  • Geriatric depression
  • PET
  • Spectroscopy

ASJC Scopus subject areas

  • Psychiatry and Mental health


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