Functional Multi-Connectivity: A Novel Approach to Assess Multi-Way Entanglement between Networks and Voxels

Armin Iraji, Noah Lewis, Ashkan Faghiri, Zening Fu, Thomas Deramus, Anees Abrol, Shile Qi, Vince Calhoun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The interactions among brain entities, commonly computed through pair-wise functional connectivity, are assumed to be manifestations of information processing which drive function. However, this focus on large-scale networks and their pair-wise temporal interactions is likely missing important information contained within fMRI data. We propose leveraging multi-connected features at both the voxel- and network-level to capture 'multi-way entanglement' between networks and voxels, providing improved resolution of interconnected brain functional hierarchy. Entanglement refers to each brain network being heavily enmeshed with the activity of other networks. Under our multi-connectivity assumption, elements of a system simultaneously communicate and interact with each other through multiple pathways. As such we move beyond the typical pair-wise temporal partial or full correlation. We propose a framework to estimate functional multi-connectivity (FMC) by computing the relationship between system-wide connections of intrinsic connectivity networks (ICNs). Results show that FMC obtains information which is different from standard pair-wise analyses.

Original languageEnglish (US)
Title of host publicationISBI 2020 - 2020 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages1698-1701
Number of pages4
ISBN (Electronic)9781538693308
DOIs
StatePublished - Apr 2020
Externally publishedYes
Event17th IEEE International Symposium on Biomedical Imaging, ISBI 2020 - Iowa City, United States
Duration: Apr 3 2020Apr 7 2020

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2020-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference17th IEEE International Symposium on Biomedical Imaging, ISBI 2020
CountryUnited States
CityIowa City
Period4/3/204/7/20

Keywords

  • functional connectivity
  • functional entanglement
  • intrinsic brain network (ICN)
  • resting state fMRI (rsfMRI)
  • Schizophrenia

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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