Functional MRI study of a serial reaction time task in Huntington's disease

Jin Suh Kim, Sarah A.J. Reading, Thomas Brashers-Krug, Vince D. Calhoun, Christopher A. Ross, Godfrey D. Pearlson

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate pathophysiological changes at an early stage of clinical Huntington's disease (HD) using a functional magnetic resonance imaging (fMRI) study and a serial reaction time task paradigm. Mildly affected and presymptomatic HD subjects (n=8) and healthy normal controls (NC, n=12) were studied. A group behavioral effect of implicit learning was seen only in the control population. Individual statistical parametric mapping (SPM) analysis showed more consistent activation of the caudate nucleus and putamen in the NC group. In the HD group, the group average SPM showed significant activation in the right head of caudate nucleus, as well as bilateral thalami, left middle temporal, right superior temporal, right superior frontal, right middle and inferior frontal and right postcentral gyri. In the comparison of between-group differences (NC-HD), reduced activation in the HD group relative to NC was observed in the right middle frontal, left middle occipital, left precuneus, and left middle frontal gyri. The variable striatal activity in the Huntington's group suggests early functional loss possibly associated with previously demonstrated early atrophy of these same neural structures.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume131
Issue number1
DOIs
StatePublished - May 30 2004

Keywords

  • Functional MRI
  • Huntington's disease
  • Implicit learning
  • Serial reaction time
  • Striatum

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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