Functional MR to localize sustained visual attention activation in patients with attention deficit hyperactivity disorder: A pilot study

Jeffrey L. Sunshine, Jonathan S. Lewin, Dee H. Wu, David A. Miller, Robert L Findling, Michael J. Manos, Michael A. Schwartz

Research output: Contribution to journalArticle


PURPOSE: To evaluate brain cortical activation in patients with attention deficit hyperactivity disorder (ADHD) and to provide an initial comparison between activates regions in ADHD subjects and those previously localized in an unaffected population. METHOD: Ten patients with ADHD underwent imaging with a functional blood oxygen level-dependent MF technique during sustained visual vigilance. Pixel activation was inspected visually and statistical group analysis was performed. RESULTS: Activation was seen over the bilateral middle frontal gyri, the superior parietal lobules, and the inferior parietal lobules. The predominant activity occurred in the right middle frontal gyrus. Application of an additional statistical constraint reveal d significant activity in the right inferior and left superior parietal lobules. CONCLUSION: ADHD patients effectively tolerate the necessary MR imaging constraints despite their difficulty with confinement and immobility. Single section functional MR imaging revealed activation in brain regions known to be involved in the maintenance of attention in healthy subjects responding to auditory, tactile, or visual stimulation; additional areas of activity that were identified may represent true abnormal regions in the affected population or artifacts.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number4
Publication statusPublished - Apr 1997
Externally publishedYes



  • Brain, magnetic resonance
  • Magnetic resonance, functional

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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